Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

The aim of this study was to determine whether and how pan-CD44 protein expression in leukoplakia tissues correlates with positive SolCD44 test presence and their role in oral leukoplakia. SolCD44 and total protein expression in saliva were determined using an OncAlert<sup>®</sup> Oral C...

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Autores principales:	Ingrīda Čēma, Madara Dzudzilo, Regīna Kleina, Ivanda Franckevica, Šimons Svirskis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CD44 antigen oral leukoplakia soluble CD44 total protein exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/01fd815d61514d7e8df4af01d43d0607
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spelling	oai:doaj.org-article:01fd815d61514d7e8df4af01d43d06072021-11-25T17:03:25ZCorrelation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues10.3390/cancers132257392072-6694https://doaj.org/article/01fd815d61514d7e8df4af01d43d06072021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5739https://doaj.org/toc/2072-6694The aim of this study was to determine whether and how pan-CD44 protein expression in leukoplakia tissues correlates with positive SolCD44 test presence and their role in oral leukoplakia. SolCD44 and total protein expression in saliva were determined using an OncAlert<sup>®</sup> Oral Cancer Rapid test. Comparison of paired associations of total protein, SolCD44, mean number of CD44 expressed epithelial layers in leukoplakia tissue, and macrophages below the basement membrane between control group and patients with leukoplakia showed statistically significant results (<i>p</i> < 0.0001). It is shown that the total protein indicates low or elevated risk of possible malignant transformation processes in leukoplakia. Statistically significant differences between higher total protein level and clinical forms of oral leukoplakia (<i>p</i> < 0.0001), as well as CD44-labeled epithelial cell layer decrease (<i>p</i> < 0.0001), were found. This possibly points to the onset of the stemness loss in leukoplakia tissue. CD9 antigen expression in the exosomes of the oral epithelium explained the intercellular flow of SolCD44 and other fluids in the leukoplakia area. We conclude that the OncAlert<sup>®</sup> Oral Cancer Rapid test is a valuable screening method in daily clinical practice, in terms of complementing clinical diagnostics methods and to assess the potential for early malignancy.Ingrīda ČēmaMadara DzudziloRegīna KleinaIvanda FranckevicaŠimons SvirskisMDPI AGarticleCD44 antigenoral leukoplakiasoluble CD44total proteinexosomesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5739, p 5739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD44 antigen oral leukoplakia soluble CD44 total protein exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CD44 antigen oral leukoplakia soluble CD44 total protein exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ingrīda Čēma Madara Dzudzilo Regīna Kleina Ivanda Franckevica Šimons Svirskis Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
description	The aim of this study was to determine whether and how pan-CD44 protein expression in leukoplakia tissues correlates with positive SolCD44 test presence and their role in oral leukoplakia. SolCD44 and total protein expression in saliva were determined using an OncAlert<sup>®</sup> Oral Cancer Rapid test. Comparison of paired associations of total protein, SolCD44, mean number of CD44 expressed epithelial layers in leukoplakia tissue, and macrophages below the basement membrane between control group and patients with leukoplakia showed statistically significant results (<i>p</i> < 0.0001). It is shown that the total protein indicates low or elevated risk of possible malignant transformation processes in leukoplakia. Statistically significant differences between higher total protein level and clinical forms of oral leukoplakia (<i>p</i> < 0.0001), as well as CD44-labeled epithelial cell layer decrease (<i>p</i> < 0.0001), were found. This possibly points to the onset of the stemness loss in leukoplakia tissue. CD9 antigen expression in the exosomes of the oral epithelium explained the intercellular flow of SolCD44 and other fluids in the leukoplakia area. We conclude that the OncAlert<sup>®</sup> Oral Cancer Rapid test is a valuable screening method in daily clinical practice, in terms of complementing clinical diagnostics methods and to assess the potential for early malignancy.
format	article
author	Ingrīda Čēma Madara Dzudzilo Regīna Kleina Ivanda Franckevica Šimons Svirskis
author_facet	Ingrīda Čēma Madara Dzudzilo Regīna Kleina Ivanda Franckevica Šimons Svirskis
author_sort	Ingrīda Čēma
title	Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
title_short	Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
title_full	Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
title_fullStr	Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
title_full_unstemmed	Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
title_sort	correlation of soluble cd44 expression in saliva and cd44 protein in oral leukoplakia tissues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/01fd815d61514d7e8df4af01d43d0607
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Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

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