Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.

Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium...

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Autores principales:	Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jones
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/020431432a1f4c968396a817fd88776f
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spelling	oai:doaj.org-article:020431432a1f4c968396a817fd88776f2021-11-18T08:45:25ZTau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.1932-620310.1371/journal.pone.0080834https://doaj.org/article/020431432a1f4c968396a817fd88776f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278327/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes in calcium by utilizing in vivo calcium imaging in adult rTg4510 mice that exhibit severe tau pathology due to over-expression of human mutant P301L tau. We observe prominent dendritic spine loss without disruptions in calcium homeostasis, indicating that tangles do not disrupt this fundamental feature of neuronal health, and that tau likely induces spine loss in a calcium-independent manner.Katherine J KopeikinaSusanne WegmannRose PitstickGeorge A CarlsonBrian J BacskaiRebecca A BetenskyBradley T HymanTara L Spires-JonesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80834 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
description	Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes in calcium by utilizing in vivo calcium imaging in adult rTg4510 mice that exhibit severe tau pathology due to over-expression of human mutant P301L tau. We observe prominent dendritic spine loss without disruptions in calcium homeostasis, indicating that tangles do not disrupt this fundamental feature of neuronal health, and that tau likely induces spine loss in a calcium-independent manner.
format	article
author	Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones
author_facet	Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones
author_sort	Katherine J Kopeikina
title	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
title_short	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
title_full	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
title_fullStr	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
title_full_unstemmed	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
title_sort	tau causes synapse loss without disrupting calcium homeostasis in the rtg4510 model of tauopathy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/020431432a1f4c968396a817fd88776f
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_version_	1718421302952329216

Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.

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