A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters

Abstract Peritonitis is a common complication of peritoneal dialysis (PD). Our root cause analysis allowed to attribute some cases to leakage of the PD catheter. Accordingly, a clinically based stress test study on potential material damage issues of PD catheters was performed, focusing on material...

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Autores principales:	Matthias Klingele, Martin Carstens, Lea Baerens, Matthias W. Laschke, Wolfgang Metzger, Danilo Fliser, Clemens M. Meier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02043db1f4f74808a69a4d97eabd6adc
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spelling	oai:doaj.org-article:02043db1f4f74808a69a4d97eabd6adc2021-12-02T15:43:17ZA material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters10.1038/s41598-021-89643-02045-2322https://doaj.org/article/02043db1f4f74808a69a4d97eabd6adc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89643-0https://doaj.org/toc/2045-2322Abstract Peritonitis is a common complication of peritoneal dialysis (PD). Our root cause analysis allowed to attribute some cases to leakage of the PD catheter. Accordingly, a clinically based stress test study on potential material damage issues of PD catheters was performed, focusing on material damage caused by cleaning, de- and attachment procedures during dialysate changes and on the individual storage methods of PD catheters between dialysate changes. PD catheters were exposed to both chemical stress by repeating dialysate-flow and physical stress simulating de- and connecting, fixation, pressure, flexing, folding etc.—simulating standard clinical daily routine of 8–10 years PD catheter usage. Potentially by normal usage caused damages should be then detected by intraluminal pressure, light- and electron microscopy. The multi-step visual control showed no obvious damages on PD catheters nor any leakage or barrier indulgence. Our tests simulating daily routine usage of PD catheters for several years could not detect any material defects under chemical or physical stress. Hence, we presume that most PD catheter damages, as identified cause for peritonitis in some of our patients, may be due to accidental, unnoticed external damage (e.g. through scissors, while changing dressings) or neglecting PD catheter handling specifications.Matthias KlingeleMartin CarstensLea BaerensMatthias W. LaschkeWolfgang MetzgerDanilo FliserClemens M. MeierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthias Klingele Martin Carstens Lea Baerens Matthias W. Laschke Wolfgang Metzger Danilo Fliser Clemens M. Meier A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
description	Abstract Peritonitis is a common complication of peritoneal dialysis (PD). Our root cause analysis allowed to attribute some cases to leakage of the PD catheter. Accordingly, a clinically based stress test study on potential material damage issues of PD catheters was performed, focusing on material damage caused by cleaning, de- and attachment procedures during dialysate changes and on the individual storage methods of PD catheters between dialysate changes. PD catheters were exposed to both chemical stress by repeating dialysate-flow and physical stress simulating de- and connecting, fixation, pressure, flexing, folding etc.—simulating standard clinical daily routine of 8–10 years PD catheter usage. Potentially by normal usage caused damages should be then detected by intraluminal pressure, light- and electron microscopy. The multi-step visual control showed no obvious damages on PD catheters nor any leakage or barrier indulgence. Our tests simulating daily routine usage of PD catheters for several years could not detect any material defects under chemical or physical stress. Hence, we presume that most PD catheter damages, as identified cause for peritonitis in some of our patients, may be due to accidental, unnoticed external damage (e.g. through scissors, while changing dressings) or neglecting PD catheter handling specifications.
format	article
author	Matthias Klingele Martin Carstens Lea Baerens Matthias W. Laschke Wolfgang Metzger Danilo Fliser Clemens M. Meier
author_facet	Matthias Klingele Martin Carstens Lea Baerens Matthias W. Laschke Wolfgang Metzger Danilo Fliser Clemens M. Meier
author_sort	Matthias Klingele
title	A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
title_short	A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
title_full	A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
title_fullStr	A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
title_full_unstemmed	A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters
title_sort	material stress test study on occurrence of leakage and material failure of peritoneal dialysis (pd) catheters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02043db1f4f74808a69a4d97eabd6adc
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A material stress test study on occurrence of leakage and material failure of peritoneal dialysis (PD) catheters

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