Delivery of pDNA to the Lung by Lipopolyplexes Using <i>N</i>-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

Delivery of pDNA to the Lung by Lipopolyplexes Using <i>N</i>-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-<i>O</i>-octadecenyl-3-trimethylammonium propane (DOTMA), and <i>N</i>-lauroylsarcosine (LS). The lipopolyplex exhibited an extremely high gene expression in the lung...

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Autores principales: Tomoaki Kurosaki, Hiroki Kanda, Junya Hashizume, Kayoko Sato, Hitomi Harasawa, Tadahiro Nakamura, Hitoshi Sasaki, Yukinobu Kodama
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
gene delivery
shRNA
nanoparticles
pulmonary fibrosis
<i>N</i>-lauroylsarcosine
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/0208892e048c44ed97c76acfa0360944
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https://doaj.org/article/0208892e048c44ed97c76acfa0360944

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