Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization

Abstract We assessed the associations of genetically instrumented blood sucrose with risk of coronary heart disease (CHD) and its risk factors (i.e., type 2 diabetes, adiposity, blood pressure, lipids, and glycaemic traits), using two-sample Mendelian randomization. We used blood fructose as a valid...

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Autores principales:	Ting Zhang, Shiu Lun Au Yeung, C. Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/020a3e8b5d2c424cb1398fde3c902bbc
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spelling	oai:doaj.org-article:020a3e8b5d2c424cb1398fde3c902bbc2021-12-02T12:33:05ZAssociation of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization10.1038/s41598-020-78685-52045-2322https://doaj.org/article/020a3e8b5d2c424cb1398fde3c902bbc2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78685-5https://doaj.org/toc/2045-2322Abstract We assessed the associations of genetically instrumented blood sucrose with risk of coronary heart disease (CHD) and its risk factors (i.e., type 2 diabetes, adiposity, blood pressure, lipids, and glycaemic traits), using two-sample Mendelian randomization. We used blood fructose as a validation exposure. Dental caries was a positive control outcome. We selected genetic variants strongly (P < 5 × 10–6) associated with blood sucrose or fructose as instrumental variables and applied them to summary statistics from the largest available genome-wide association studies of the outcomes. Inverse-variance weighting was used as main analysis. Sensitivity analyses included weighted median, MR-Egger and MR-PRESSO. Genetically higher blood sucrose was positively associated with the control outcome, dental caries (odds ratio [OR] 1.04 per log10 transformed effect size [median-normalized standard deviation] increase, 95% confidence interval [CI] 1.002–1.08, P = 0.04), but this association did not withstand allowing for multiple testing. The estimate for blood fructose was in the same direction. Genetically instrumented blood sucrose was not clearly associated with CHD (OR 1.01, 95% CI 0.997–1.02, P = 0.14), nor with its risk factors. Findings were similar for blood fructose. Our study found some evidence of the expected detrimental effect of sucrose on dental caries but no effect on CHD. Given a small effect on CHD cannot be excluded, further investigation with stronger genetic predictors is required.Ting ZhangShiu Lun Au YeungC. Mary SchoolingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting Zhang Shiu Lun Au Yeung C. Mary Schooling Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
description	Abstract We assessed the associations of genetically instrumented blood sucrose with risk of coronary heart disease (CHD) and its risk factors (i.e., type 2 diabetes, adiposity, blood pressure, lipids, and glycaemic traits), using two-sample Mendelian randomization. We used blood fructose as a validation exposure. Dental caries was a positive control outcome. We selected genetic variants strongly (P < 5 × 10–6) associated with blood sucrose or fructose as instrumental variables and applied them to summary statistics from the largest available genome-wide association studies of the outcomes. Inverse-variance weighting was used as main analysis. Sensitivity analyses included weighted median, MR-Egger and MR-PRESSO. Genetically higher blood sucrose was positively associated with the control outcome, dental caries (odds ratio [OR] 1.04 per log10 transformed effect size [median-normalized standard deviation] increase, 95% confidence interval [CI] 1.002–1.08, P = 0.04), but this association did not withstand allowing for multiple testing. The estimate for blood fructose was in the same direction. Genetically instrumented blood sucrose was not clearly associated with CHD (OR 1.01, 95% CI 0.997–1.02, P = 0.14), nor with its risk factors. Findings were similar for blood fructose. Our study found some evidence of the expected detrimental effect of sucrose on dental caries but no effect on CHD. Given a small effect on CHD cannot be excluded, further investigation with stronger genetic predictors is required.
format	article
author	Ting Zhang Shiu Lun Au Yeung C. Mary Schooling
author_facet	Ting Zhang Shiu Lun Au Yeung C. Mary Schooling
author_sort	Ting Zhang
title	Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
title_short	Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
title_full	Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
title_fullStr	Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
title_full_unstemmed	Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
title_sort	association of genetically predicted blood sucrose with coronary heart disease and its risk factors in mendelian randomization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/020a3e8b5d2c424cb1398fde3c902bbc
work_keys_str_mv	AT tingzhang associationofgeneticallypredictedbloodsucrosewithcoronaryheartdiseaseanditsriskfactorsinmendelianrandomization AT shiulunauyeung associationofgeneticallypredictedbloodsucrosewithcoronaryheartdiseaseanditsriskfactorsinmendelianrandomization AT cmaryschooling associationofgeneticallypredictedbloodsucrosewithcoronaryheartdiseaseanditsriskfactorsinmendelianrandomization
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Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization

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