Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic bio...

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Autores principales: Huaqiang Zhou, Yi Hu, Rongzhen Luo, Yuanyuan Zhao, Hui Pan, Liyan Ji, Ting Zhou, Lanjun Zhang, Hao Long, Jianhua Fu, Zhesheng Wen, Siyu Wang, Xin Wang, Peng Lin, Haoxian Yang, Junye Wang, Mengmeng Song, Xin Yi, Ling Yang, Xuefang Xia, Yanfang Guan, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Yan Huang, Pansong Li, Yaxiong Zhang, Ningning Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/020afdb69e754b149efff3166042e51a
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spelling oai:doaj.org-article:020afdb69e754b149efff3166042e51a2021-12-02T17:24:12ZMulti-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer10.1038/s41467-021-25787-x2041-1723https://doaj.org/article/020afdb69e754b149efff3166042e51a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25787-xhttps://doaj.org/toc/2041-1723Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.Huaqiang ZhouYi HuRongzhen LuoYuanyuan ZhaoHui PanLiyan JiTing ZhouLanjun ZhangHao LongJianhua FuZhesheng WenSiyu WangXin WangPeng LinHaoxian YangJunye WangMengmeng SongXin YiLing YangXuefang XiaYanfang GuanWenfeng FangYunpeng YangShaodong HongYan HuangPansong LiYaxiong ZhangNingning ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Huaqiang Zhou
Yi Hu
Rongzhen Luo
Yuanyuan Zhao
Hui Pan
Liyan Ji
Ting Zhou
Lanjun Zhang
Hao Long
Jianhua Fu
Zhesheng Wen
Siyu Wang
Xin Wang
Peng Lin
Haoxian Yang
Junye Wang
Mengmeng Song
Xin Yi
Ling Yang
Xuefang Xia
Yanfang Guan
Wenfeng Fang
Yunpeng Yang
Shaodong Hong
Yan Huang
Pansong Li
Yaxiong Zhang
Ningning Zhou
Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
description Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.
format article
author Huaqiang Zhou
Yi Hu
Rongzhen Luo
Yuanyuan Zhao
Hui Pan
Liyan Ji
Ting Zhou
Lanjun Zhang
Hao Long
Jianhua Fu
Zhesheng Wen
Siyu Wang
Xin Wang
Peng Lin
Haoxian Yang
Junye Wang
Mengmeng Song
Xin Yi
Ling Yang
Xuefang Xia
Yanfang Guan
Wenfeng Fang
Yunpeng Yang
Shaodong Hong
Yan Huang
Pansong Li
Yaxiong Zhang
Ningning Zhou
author_facet Huaqiang Zhou
Yi Hu
Rongzhen Luo
Yuanyuan Zhao
Hui Pan
Liyan Ji
Ting Zhou
Lanjun Zhang
Hao Long
Jianhua Fu
Zhesheng Wen
Siyu Wang
Xin Wang
Peng Lin
Haoxian Yang
Junye Wang
Mengmeng Song
Xin Yi
Ling Yang
Xuefang Xia
Yanfang Guan
Wenfeng Fang
Yunpeng Yang
Shaodong Hong
Yan Huang
Pansong Li
Yaxiong Zhang
Ningning Zhou
author_sort Huaqiang Zhou
title Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
title_short Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
title_full Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
title_fullStr Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
title_full_unstemmed Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
title_sort multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/020afdb69e754b149efff3166042e51a
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