Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)

Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)

Abstract Background Functional recovery of patients with clinical and subclinical psychosis is associated with clinical, neuropsychological and developmental factors. Less is known about how these factors predict functional outcomes in the same models. We investigated functional outcomes and their p...

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Autores principales: Raimo K. R. Salokangas, Tiina From, Tuula Ilonen, Sinikka Luutonen, Markus Heinimaa, Reetta-Liina Armio, Heikki Laurikainen, Maija Walta, Janina Paju, Anna Toivonen, Päivi Jalo, Lauri Tuominen, Jarmo Hietala
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Functional outcome
Psychotic disorders
Clinical high risk of psychosis
Premorbid adjustment
Disorganization symptoms
Negative symptoms
Psychiatry
RC435-571
Acceso en línea:https://doaj.org/article/020b9a2c5d3040dc91b0aca36eef6038
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spelling oai:doaj.org-article:020b9a2c5d3040dc91b0aca36eef60382021-12-05T12:06:07ZShort-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)10.1186/s12888-021-03516-41471-244Xhttps://doaj.org/article/020b9a2c5d3040dc91b0aca36eef60382021-12-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03516-4https://doaj.org/toc/1471-244XAbstract Background Functional recovery of patients with clinical and subclinical psychosis is associated with clinical, neuropsychological and developmental factors. Less is known about how these factors predict functional outcomes in the same models. We investigated functional outcomes and their predictors in patients with first-episode psychosis (FEP) or a confirmed or nonconfirmed clinical high risk of psychosis (CHR-P vs. CHR-N). Methods Altogether, 130 patients with FEP, 60 patients with CHR-P and 47 patients with CHR-N were recruited and extensively examined at baseline (T0) and 9 (T1) and 18 (T2) months later. Global Assessment of Functioning (GAF) at T0, T1 and T2 and psychotic, depression, and anxiety symptoms at T1 and T2 were assessed. Functional outcomes were predicted using multivariate repeated ANOVA. Results During follow-up, the GAF score improved significantly in patients with FEP and CHR-P but not in patients with CHR-N. A single marital status, low basic education level, poor work situation, disorganization symptoms, perceptual deficits, and poor premorbid adjustment in patients with FEP, disorganization symptoms and poor premorbid adjustment in patients with CHR-P, and a low basic education level, poor work situation and general symptoms in patients with CHR-N predicted poor functional outcomes. Psychotic symptoms at T1 in patients with FEP and psychotic and depression symptoms at T1 and anxiety symptoms at T2 in patients with CHR-P were associated with poor functioning. Conclusions In patients with FEP and CHR-P, poor premorbid adjustment and disorganization symptomatology are common predictors of the functional outcome, while a low education level and poor work situation predict worse functional outcomes in patients with FEP and CHR-N. Interventions aimed at improving the ability to work and study are most important in improving the functioning of patients with clinical or subclinical psychosis.Raimo K. R. SalokangasTiina FromTuula IlonenSinikka LuutonenMarkus HeinimaaReetta-Liina ArmioHeikki LaurikainenMaija WaltaJanina PajuAnna ToivonenPäivi JaloLauri TuominenJarmo HietalaBMCarticleFunctional outcomePsychotic disordersClinical high risk of psychosisPremorbid adjustmentDisorganization symptomsNegative symptomsPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Functional outcome
Psychotic disorders
Clinical high risk of psychosis
Premorbid adjustment
Disorganization symptoms
Negative symptoms
Psychiatry
RC435-571
spellingShingle Functional outcome
Psychotic disorders
Clinical high risk of psychosis
Premorbid adjustment
Disorganization symptoms
Negative symptoms
Psychiatry
RC435-571
Raimo K. R. Salokangas
Tiina From
Tuula Ilonen
Sinikka Luutonen
Markus Heinimaa
Reetta-Liina Armio
Heikki Laurikainen
Maija Walta
Janina Paju
Anna Toivonen
Päivi Jalo
Lauri Tuominen
Jarmo Hietala
Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
description Abstract Background Functional recovery of patients with clinical and subclinical psychosis is associated with clinical, neuropsychological and developmental factors. Less is known about how these factors predict functional outcomes in the same models. We investigated functional outcomes and their predictors in patients with first-episode psychosis (FEP) or a confirmed or nonconfirmed clinical high risk of psychosis (CHR-P vs. CHR-N). Methods Altogether, 130 patients with FEP, 60 patients with CHR-P and 47 patients with CHR-N were recruited and extensively examined at baseline (T0) and 9 (T1) and 18 (T2) months later. Global Assessment of Functioning (GAF) at T0, T1 and T2 and psychotic, depression, and anxiety symptoms at T1 and T2 were assessed. Functional outcomes were predicted using multivariate repeated ANOVA. Results During follow-up, the GAF score improved significantly in patients with FEP and CHR-P but not in patients with CHR-N. A single marital status, low basic education level, poor work situation, disorganization symptoms, perceptual deficits, and poor premorbid adjustment in patients with FEP, disorganization symptoms and poor premorbid adjustment in patients with CHR-P, and a low basic education level, poor work situation and general symptoms in patients with CHR-N predicted poor functional outcomes. Psychotic symptoms at T1 in patients with FEP and psychotic and depression symptoms at T1 and anxiety symptoms at T2 in patients with CHR-P were associated with poor functioning. Conclusions In patients with FEP and CHR-P, poor premorbid adjustment and disorganization symptomatology are common predictors of the functional outcome, while a low education level and poor work situation predict worse functional outcomes in patients with FEP and CHR-N. Interventions aimed at improving the ability to work and study are most important in improving the functioning of patients with clinical or subclinical psychosis.
format article
author Raimo K. R. Salokangas
Tiina From
Tuula Ilonen
Sinikka Luutonen
Markus Heinimaa
Reetta-Liina Armio
Heikki Laurikainen
Maija Walta
Janina Paju
Anna Toivonen
Päivi Jalo
Lauri Tuominen
Jarmo Hietala
author_facet Raimo K. R. Salokangas
Tiina From
Tuula Ilonen
Sinikka Luutonen
Markus Heinimaa
Reetta-Liina Armio
Heikki Laurikainen
Maija Walta
Janina Paju
Anna Toivonen
Päivi Jalo
Lauri Tuominen
Jarmo Hietala
author_sort Raimo K. R. Salokangas
title Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
title_short Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
title_full Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
title_fullStr Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
title_full_unstemmed Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS)
title_sort short-term functional outcome in psychotic patients: results of the turku early psychosis study (teps)
publisher BMC
publishDate 2021
url https://doaj.org/article/020b9a2c5d3040dc91b0aca36eef6038
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