Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells.

Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells.

Heme is an essential cofactor for enzymes of the electron transport chain (ETC) and ATP synthesis in mitochondrial oxidative phosphorylation (OXPHOS). Heme also binds to and destabilizes Bach1, a transcription regulator that controls expression of several groups of genes important for glycolysis, ET...

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Autores principales: Pritpal Kaur, Shreya Nagar, Madhura Bhagwat, Mohammad Uddin, Yan Zhu, Ivana Vancurova, Ales Vancura
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/020bef64cbbe4de08832db9cc3b7ff18
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