Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder

Abstract Cognitive impairment (CI) is reported in 29–57% of patients with neuromyelitis optica spectrum disorder (NMOSD). However, the pathophysiology underlying CI in NMOSD is poorly understood. The present study aims to investigate the predictive values of various conventional and quantitative MRI...

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Autores principales:	Su-Hyun Kim, Eun Young Park, Boram Park, Jae-Won Hyun, Na Young Park, AeRan Joung, Sang Hyun Lee, Ho Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/020cb1c13de0458497e69d66adc021d4
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spelling	oai:doaj.org-article:020cb1c13de0458497e69d66adc021d42021-12-02T12:30:27ZMultimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder10.1038/s41598-017-08889-92045-2322https://doaj.org/article/020cb1c13de0458497e69d66adc021d42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08889-9https://doaj.org/toc/2045-2322Abstract Cognitive impairment (CI) is reported in 29–57% of patients with neuromyelitis optica spectrum disorder (NMOSD). However, the pathophysiology underlying CI in NMOSD is poorly understood. The present study aims to investigate the predictive values of various conventional and quantitative MRI parameters for cognitive performance in patients with NMOSD. Neurological assessment and conventional, diffusion tensor, and volumetric MRI sequences were collected form 73 patients with NMOSD and 44 healthy controls (HCs). Patients with ≥3 failed tests were considered to have CI. Brain lesion load, gray matter (GM) and white matter (WM) atrophy, deep GM (DGM) atrophy, cortical thickness, and diffuse microstructural WM damage were assessed. Twenty-three (32%) patients with NMOSD had CI. Compared to cognitively preserved (CP) individuals, patients with CI had atrophy in the WM, thalamus, and caudate, decreased fractional anisotropy (FA) and increased mean diffusivity in their WM. A multivariate model indicated that mean FA values in the WM and volume in the nucleus accumbens (NAc) were associated with overall cognition (p = 0.002 and p = 0.008, respectively). Diffuse microstructural damage in the WM and DGM atrophy in the NAc are the strongest predictors of cognitive impairment in patients with NMOSD.Su-Hyun KimEun Young ParkBoram ParkJae-Won HyunNa Young ParkAeRan JoungSang Hyun LeeHo Jin KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su-Hyun Kim Eun Young Park Boram Park Jae-Won Hyun Na Young Park AeRan Joung Sang Hyun Lee Ho Jin Kim Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
description	Abstract Cognitive impairment (CI) is reported in 29–57% of patients with neuromyelitis optica spectrum disorder (NMOSD). However, the pathophysiology underlying CI in NMOSD is poorly understood. The present study aims to investigate the predictive values of various conventional and quantitative MRI parameters for cognitive performance in patients with NMOSD. Neurological assessment and conventional, diffusion tensor, and volumetric MRI sequences were collected form 73 patients with NMOSD and 44 healthy controls (HCs). Patients with ≥3 failed tests were considered to have CI. Brain lesion load, gray matter (GM) and white matter (WM) atrophy, deep GM (DGM) atrophy, cortical thickness, and diffuse microstructural WM damage were assessed. Twenty-three (32%) patients with NMOSD had CI. Compared to cognitively preserved (CP) individuals, patients with CI had atrophy in the WM, thalamus, and caudate, decreased fractional anisotropy (FA) and increased mean diffusivity in their WM. A multivariate model indicated that mean FA values in the WM and volume in the nucleus accumbens (NAc) were associated with overall cognition (p = 0.002 and p = 0.008, respectively). Diffuse microstructural damage in the WM and DGM atrophy in the NAc are the strongest predictors of cognitive impairment in patients with NMOSD.
format	article
author	Su-Hyun Kim Eun Young Park Boram Park Jae-Won Hyun Na Young Park AeRan Joung Sang Hyun Lee Ho Jin Kim
author_facet	Su-Hyun Kim Eun Young Park Boram Park Jae-Won Hyun Na Young Park AeRan Joung Sang Hyun Lee Ho Jin Kim
author_sort	Su-Hyun Kim
title	Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
title_short	Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
title_full	Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
title_fullStr	Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
title_full_unstemmed	Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
title_sort	multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/020cb1c13de0458497e69d66adc021d4
work_keys_str_mv	AT suhyunkim multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT eunyoungpark multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT borampark multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT jaewonhyun multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT nayoungpark multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT aeranjoung multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT sanghyunlee multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder AT hojinkim multimodalmagneticresonanceimaginginrelationtocognitiveimpairmentinneuromyelitisopticaspectrumdisorder
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Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder

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