Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor.
To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 select...
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oai:doaj.org-article:021168f59fb54632aa78ffc17643d7d32021-11-25T06:28:47ZUpdating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor.1932-620310.1371/journal.pone.0007447https://doaj.org/article/021168f59fb54632aa78ffc17643d7d32009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19823670/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 selected tribal populations of India. On the basis of complete mtDNA sequencing, we identified 12 new haplogroups--M53 to M64; redefined/ascertained and characterized haplogroups M2, M3, M4, M5, M6, M8'C'Z, M9, M10, M11, M12-G, D, M18, M30, M33, M35, M37, M38, M39, M40, M41, M43, M45 and M49, which were previously described by control and/or coding-region polymorphisms. Our results indicate that the mtDNA lineages reported in the present study (except East Asian lineages M8'C'Z, M9, M10, M11, M12-G, D) are restricted to Indian region.The deep rooted lineages of macrohaplogroup 'M' suggest in-situ origin of these haplogroups in India. Most of these deep rooting lineages are represented by multiple ethnic/linguist groups of India. Hierarchical analysis of molecular variation (AMOVA) shows substantial subdivisions among the tribes of India (Fst = 0.16164). The current Indian mtDNA gene pool was shaped by the initial settlers and was galvanized by minor events of gene flow from the east and west to the restricted zones. Northeast Indian mtDNA pool harbors region specific lineages, other Indian lineages and East Asian lineages. We also suggest the establishment of an East Asian gene in North East India through admixture rather than replacement.Adimoolam ChandrasekarSatish KumarJwalapuram SreenathBishwa Nath SarkarBhaskar Pralhad UradeSujit MallickSyam Sundar BandopadhyayPinuma BaruaSubihra Sankar BarikDebasish BasuUttaravalli KiranProdyot GangopadhyayRamesh SahaniBhagavatula Venkata Ravi PrasadShampa GangopadhyayGandikota Rama LakshmiRajasekhara Reddy RavuriKoneru PadmajaPulamaghatta N VenugopalMadhu Bala SharmaVadlamudi Raghavendra RaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 10, p e7447 (2009) |
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Medicine R Science Q Adimoolam Chandrasekar Satish Kumar Jwalapuram Sreenath Bishwa Nath Sarkar Bhaskar Pralhad Urade Sujit Mallick Syam Sundar Bandopadhyay Pinuma Barua Subihra Sankar Barik Debasish Basu Uttaravalli Kiran Prodyot Gangopadhyay Ramesh Sahani Bhagavatula Venkata Ravi Prasad Shampa Gangopadhyay Gandikota Rama Lakshmi Rajasekhara Reddy Ravuri Koneru Padmaja Pulamaghatta N Venugopal Madhu Bala Sharma Vadlamudi Raghavendra Rao Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| description |
To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 selected tribal populations of India. On the basis of complete mtDNA sequencing, we identified 12 new haplogroups--M53 to M64; redefined/ascertained and characterized haplogroups M2, M3, M4, M5, M6, M8'C'Z, M9, M10, M11, M12-G, D, M18, M30, M33, M35, M37, M38, M39, M40, M41, M43, M45 and M49, which were previously described by control and/or coding-region polymorphisms. Our results indicate that the mtDNA lineages reported in the present study (except East Asian lineages M8'C'Z, M9, M10, M11, M12-G, D) are restricted to Indian region.The deep rooted lineages of macrohaplogroup 'M' suggest in-situ origin of these haplogroups in India. Most of these deep rooting lineages are represented by multiple ethnic/linguist groups of India. Hierarchical analysis of molecular variation (AMOVA) shows substantial subdivisions among the tribes of India (Fst = 0.16164). The current Indian mtDNA gene pool was shaped by the initial settlers and was galvanized by minor events of gene flow from the east and west to the restricted zones. Northeast Indian mtDNA pool harbors region specific lineages, other Indian lineages and East Asian lineages. We also suggest the establishment of an East Asian gene in North East India through admixture rather than replacement. |
| format |
article |
| author |
Adimoolam Chandrasekar Satish Kumar Jwalapuram Sreenath Bishwa Nath Sarkar Bhaskar Pralhad Urade Sujit Mallick Syam Sundar Bandopadhyay Pinuma Barua Subihra Sankar Barik Debasish Basu Uttaravalli Kiran Prodyot Gangopadhyay Ramesh Sahani Bhagavatula Venkata Ravi Prasad Shampa Gangopadhyay Gandikota Rama Lakshmi Rajasekhara Reddy Ravuri Koneru Padmaja Pulamaghatta N Venugopal Madhu Bala Sharma Vadlamudi Raghavendra Rao |
| author_facet |
Adimoolam Chandrasekar Satish Kumar Jwalapuram Sreenath Bishwa Nath Sarkar Bhaskar Pralhad Urade Sujit Mallick Syam Sundar Bandopadhyay Pinuma Barua Subihra Sankar Barik Debasish Basu Uttaravalli Kiran Prodyot Gangopadhyay Ramesh Sahani Bhagavatula Venkata Ravi Prasad Shampa Gangopadhyay Gandikota Rama Lakshmi Rajasekhara Reddy Ravuri Koneru Padmaja Pulamaghatta N Venugopal Madhu Bala Sharma Vadlamudi Raghavendra Rao |
| author_sort |
Adimoolam Chandrasekar |
| title |
Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| title_short |
Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| title_full |
Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| title_fullStr |
Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| title_full_unstemmed |
Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. |
| title_sort |
updating phylogeny of mitochondrial dna macrohaplogroup m in india: dispersal of modern human in south asian corridor. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/021168f59fb54632aa78ffc17643d7d3 |
| work_keys_str_mv |
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