Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity

Abstract The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomo...

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Autores principales:	Rico Grundmann, Michael Rullmann, Julia Luthardt, Franziska Zientek, Georg-Alexander Becker, Marianne Patt, Mohammed K. Hankir, Matthias Blüher, Osama Sabri, Swen Hesse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0212f447969947fbb7763f9374bf9877
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spelling	oai:doaj.org-article:0212f447969947fbb7763f9374bf98772021-12-02T15:09:22ZHigher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity10.1038/s41598-020-78227-z2045-2322https://doaj.org/article/0212f447969947fbb7763f9374bf98772020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78227-zhttps://doaj.org/toc/2045-2322Abstract The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [11C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BPND were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BPND in right and left hippocampus in obesity (r = − 0.717, p < 0.001, and r = − 0.557, p = 0.006, respectively). VBM analyses revealed that higher HbA1c levels were associated with GMD in the right para-hippocampal area. Our results indicate that chronically high blood glucose levels may evoke changes in hippocampal 5-HTT levels that are in part tied to local microstructure.Rico GrundmannMichael RullmannJulia LuthardtFranziska ZientekGeorg-Alexander BeckerMarianne PattMohammed K. HankirMatthias BlüherOsama SabriSwen HesseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rico Grundmann Michael Rullmann Julia Luthardt Franziska Zientek Georg-Alexander Becker Marianne Patt Mohammed K. Hankir Matthias Blüher Osama Sabri Swen Hesse Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
description	Abstract The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [11C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BPND were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BPND in right and left hippocampus in obesity (r = − 0.717, p < 0.001, and r = − 0.557, p = 0.006, respectively). VBM analyses revealed that higher HbA1c levels were associated with GMD in the right para-hippocampal area. Our results indicate that chronically high blood glucose levels may evoke changes in hippocampal 5-HTT levels that are in part tied to local microstructure.
format	article
author	Rico Grundmann Michael Rullmann Julia Luthardt Franziska Zientek Georg-Alexander Becker Marianne Patt Mohammed K. Hankir Matthias Blüher Osama Sabri Swen Hesse
author_facet	Rico Grundmann Michael Rullmann Julia Luthardt Franziska Zientek Georg-Alexander Becker Marianne Patt Mohammed K. Hankir Matthias Blüher Osama Sabri Swen Hesse
author_sort	Rico Grundmann
title	Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
title_short	Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
title_full	Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
title_fullStr	Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
title_full_unstemmed	Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
title_sort	higher hba1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0212f447969947fbb7763f9374bf9877
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Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity

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