Deciphering the complex role of thrombospondin-1 in glioblastoma development

Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resistance to antiangiogenic therapy partially through...

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Autores principales:	Thomas Daubon, Céline Léon, Kim Clarke, Laetitia Andrique, Laura Salabert, Elodie Darbo, Raphael Pineau, Sylvaine Guérit, Marlène Maitre, Stéphane Dedieu, Albin Jeanne, Sabine Bailly, Jean-Jacques Feige, Hrvoje Miletic, Marco Rossi, Lorenzo Bello, Francesco Falciani, Rolf Bjerkvig, Andréas Bikfalvi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0213114feac44243930602814fc59d30
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spelling	oai:doaj.org-article:0213114feac44243930602814fc59d302021-12-02T16:57:20ZDeciphering the complex role of thrombospondin-1 in glioblastoma development10.1038/s41467-019-08480-y2041-1723https://doaj.org/article/0213114feac44243930602814fc59d302019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08480-yhttps://doaj.org/toc/2041-1723Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resistance to antiangiogenic therapy partially through interaction with CD47.Thomas DaubonCéline LéonKim ClarkeLaetitia AndriqueLaura SalabertElodie DarboRaphael PineauSylvaine GuéritMarlène MaitreStéphane DedieuAlbin JeanneSabine BaillyJean-Jacques FeigeHrvoje MileticMarco RossiLorenzo BelloFrancesco FalcianiRolf BjerkvigAndréas BikfalviNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Daubon Céline Léon Kim Clarke Laetitia Andrique Laura Salabert Elodie Darbo Raphael Pineau Sylvaine Guérit Marlène Maitre Stéphane Dedieu Albin Jeanne Sabine Bailly Jean-Jacques Feige Hrvoje Miletic Marco Rossi Lorenzo Bello Francesco Falciani Rolf Bjerkvig Andréas Bikfalvi Deciphering the complex role of thrombospondin-1 in glioblastoma development
description	Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resistance to antiangiogenic therapy partially through interaction with CD47.
format	article
author	Thomas Daubon Céline Léon Kim Clarke Laetitia Andrique Laura Salabert Elodie Darbo Raphael Pineau Sylvaine Guérit Marlène Maitre Stéphane Dedieu Albin Jeanne Sabine Bailly Jean-Jacques Feige Hrvoje Miletic Marco Rossi Lorenzo Bello Francesco Falciani Rolf Bjerkvig Andréas Bikfalvi
author_facet	Thomas Daubon Céline Léon Kim Clarke Laetitia Andrique Laura Salabert Elodie Darbo Raphael Pineau Sylvaine Guérit Marlène Maitre Stéphane Dedieu Albin Jeanne Sabine Bailly Jean-Jacques Feige Hrvoje Miletic Marco Rossi Lorenzo Bello Francesco Falciani Rolf Bjerkvig Andréas Bikfalvi
author_sort	Thomas Daubon
title	Deciphering the complex role of thrombospondin-1 in glioblastoma development
title_short	Deciphering the complex role of thrombospondin-1 in glioblastoma development
title_full	Deciphering the complex role of thrombospondin-1 in glioblastoma development
title_fullStr	Deciphering the complex role of thrombospondin-1 in glioblastoma development
title_full_unstemmed	Deciphering the complex role of thrombospondin-1 in glioblastoma development
title_sort	deciphering the complex role of thrombospondin-1 in glioblastoma development
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0213114feac44243930602814fc59d30
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Deciphering the complex role of thrombospondin-1 in glioblastoma development

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