Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness

Given the growing obesity rates among children, a more complete evaluation of their potential cardiometabolic risk is needed. Carotid intima-media thickness (CIMT), a marker of endothelial distress and a predictor of atherosclerotic progression in adulthood, may complete the day-to-day evaluation of...

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Autores principales:	Monica-Simina Mihuta, Corina Paul, Adrian Ciulpan, Farah Dacca, Iulian Puiu Velea, Ioana Mozos, Dana Stoian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiometabolic risk carotid intima-media thickness childhood obesity subclinical atherosclerosis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/02136f97fd11427b9e6bcff0c3d29882
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spelling	oai:doaj.org-article:02136f97fd11427b9e6bcff0c3d298822021-11-25T16:36:37ZSubclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness10.3390/app1122107212076-3417https://doaj.org/article/02136f97fd11427b9e6bcff0c3d298822021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10721https://doaj.org/toc/2076-3417Given the growing obesity rates among children, a more complete evaluation of their potential cardiometabolic risk is needed. Carotid intima-media thickness (CIMT), a marker of endothelial distress and a predictor of atherosclerotic progression in adulthood, may complete the day-to-day evaluation of children at risk. Multiple risk factors act as additional precipitant causes of atherosclerosis. We analyzed 60 patients aged 6–17 years old by measuring their CIMT using the Aixplorer MACH 30 echography machine automatic measurement software. All subjects were clinically and anamnestically assessed to identify risk factors. CIMT values are significantly higher in older children and boys. Over 20 kg weight gain during pregnancy and other at-risk disorders (<i>p</i> = 0.047), family history of cardiovascular risk (<i>p</i> = 0.049), hypertension (<i>p</i> = 0.012), and smoking (<i>p</i> = 0.015) are linked to increased CIMT. Our study also supports international data on artificial postnatal nutrition, high/low birth weight, and sedentary lifestyle being linked to increased CIMT. Significant correlations were detected between CIMT and the entire lipid panel. Weight excess and abdominal adiposity in children is clearly linked to increased CIMT. Moreover, waist circumference and TG/HDL-c are significant predictors of CIMT. Although each parameter of the lipid panel is correlated to CIMT, fasting glucose is not.Monica-Simina MihutaCorina PaulAdrian CiulpanFarah DaccaIulian Puiu VeleaIoana MozosDana StoianMDPI AGarticlecardiometabolic riskcarotid intima-media thicknesschildhood obesitysubclinical atherosclerosisTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10721, p 10721 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiometabolic risk carotid intima-media thickness childhood obesity subclinical atherosclerosis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	cardiometabolic risk carotid intima-media thickness childhood obesity subclinical atherosclerosis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Monica-Simina Mihuta Corina Paul Adrian Ciulpan Farah Dacca Iulian Puiu Velea Ioana Mozos Dana Stoian Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
description	Given the growing obesity rates among children, a more complete evaluation of their potential cardiometabolic risk is needed. Carotid intima-media thickness (CIMT), a marker of endothelial distress and a predictor of atherosclerotic progression in adulthood, may complete the day-to-day evaluation of children at risk. Multiple risk factors act as additional precipitant causes of atherosclerosis. We analyzed 60 patients aged 6–17 years old by measuring their CIMT using the Aixplorer MACH 30 echography machine automatic measurement software. All subjects were clinically and anamnestically assessed to identify risk factors. CIMT values are significantly higher in older children and boys. Over 20 kg weight gain during pregnancy and other at-risk disorders (<i>p</i> = 0.047), family history of cardiovascular risk (<i>p</i> = 0.049), hypertension (<i>p</i> = 0.012), and smoking (<i>p</i> = 0.015) are linked to increased CIMT. Our study also supports international data on artificial postnatal nutrition, high/low birth weight, and sedentary lifestyle being linked to increased CIMT. Significant correlations were detected between CIMT and the entire lipid panel. Weight excess and abdominal adiposity in children is clearly linked to increased CIMT. Moreover, waist circumference and TG/HDL-c are significant predictors of CIMT. Although each parameter of the lipid panel is correlated to CIMT, fasting glucose is not.
format	article
author	Monica-Simina Mihuta Corina Paul Adrian Ciulpan Farah Dacca Iulian Puiu Velea Ioana Mozos Dana Stoian
author_facet	Monica-Simina Mihuta Corina Paul Adrian Ciulpan Farah Dacca Iulian Puiu Velea Ioana Mozos Dana Stoian
author_sort	Monica-Simina Mihuta
title	Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
title_short	Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
title_full	Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
title_fullStr	Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
title_full_unstemmed	Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness
title_sort	subclinical atherosclerosis progression in obese children with relevant cardiometabolic risk factors can be assessed through carotid intima media thickness
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/02136f97fd11427b9e6bcff0c3d29882
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Subclinical Atherosclerosis Progression in Obese Children with Relevant Cardiometabolic Risk Factors Can Be Assessed through Carotid Intima Media Thickness

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