MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses

Abstract The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration. However, whether increased fission or fusion is beneficial for neuronal health and/or axonal growth is not entirely clear, and is...

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Autores principales:	Alexander Kreymerman, David N. Buickians, Michael M. Nahmou, Tammy Tran, Joana Galvao, Yan Wang, Nicholas Sun, Leah Bazik, Star K. Huynh, In-Jae Cho, Tomasz Boczek, Kun-Che Chang, Noelia J. Kunzevitzky, Jeffrey L. Goldberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0215dae8fa5149f99d708b4117f0df14
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spelling	oai:doaj.org-article:0215dae8fa5149f99d708b4117f0df142021-12-02T15:09:30ZMTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses10.1038/s41598-019-46956-52045-2322https://doaj.org/article/0215dae8fa5149f99d708b4117f0df142019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46956-5https://doaj.org/toc/2045-2322Abstract The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration. However, whether increased fission or fusion is beneficial for neuronal health and/or axonal growth is not entirely clear, and is likely situational and cell type-dependent. In searching for mitochondrial fission-fusion regulating proteins for improving axonal growth within the visual system, we uncover that mitochondrial fission process 1,18 kDa (MTP18/MTFP1), a pro-fission protein within the CNS, is critical to maintaining mitochondrial size and volume under normal and injury conditions, in retinal ganglion cells (RGCs). We demonstrate that MTP18’s expression is regulated by transcription factors involved in axonal growth, Kruppel-like factor (KLF) transcription factors-7 and -9, and that knockdown of MTP18 promotes axon growth. This investigation exposes MTP18’s previously unexplored role in regulating mitochondrial fission, implicates MTP18 as a downstream component of axon regenerative signaling, and ultimately lays the groundwork for investigations on the therapeutic efficacy of MTP18 expression suppression during CNS axon degenerative events.Alexander KreymermanDavid N. BuickiansMichael M. NahmouTammy TranJoana GalvaoYan WangNicholas SunLeah BazikStar K. HuynhIn-Jae ChoTomasz BoczekKun-Che ChangNoelia J. KunzevitzkyJeffrey L. GoldbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Kreymerman David N. Buickians Michael M. Nahmou Tammy Tran Joana Galvao Yan Wang Nicholas Sun Leah Bazik Star K. Huynh In-Jae Cho Tomasz Boczek Kun-Che Chang Noelia J. Kunzevitzky Jeffrey L. Goldberg MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
description	Abstract The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration. However, whether increased fission or fusion is beneficial for neuronal health and/or axonal growth is not entirely clear, and is likely situational and cell type-dependent. In searching for mitochondrial fission-fusion regulating proteins for improving axonal growth within the visual system, we uncover that mitochondrial fission process 1,18 kDa (MTP18/MTFP1), a pro-fission protein within the CNS, is critical to maintaining mitochondrial size and volume under normal and injury conditions, in retinal ganglion cells (RGCs). We demonstrate that MTP18’s expression is regulated by transcription factors involved in axonal growth, Kruppel-like factor (KLF) transcription factors-7 and -9, and that knockdown of MTP18 promotes axon growth. This investigation exposes MTP18’s previously unexplored role in regulating mitochondrial fission, implicates MTP18 as a downstream component of axon regenerative signaling, and ultimately lays the groundwork for investigations on the therapeutic efficacy of MTP18 expression suppression during CNS axon degenerative events.
format	article
author	Alexander Kreymerman David N. Buickians Michael M. Nahmou Tammy Tran Joana Galvao Yan Wang Nicholas Sun Leah Bazik Star K. Huynh In-Jae Cho Tomasz Boczek Kun-Che Chang Noelia J. Kunzevitzky Jeffrey L. Goldberg
author_facet	Alexander Kreymerman David N. Buickians Michael M. Nahmou Tammy Tran Joana Galvao Yan Wang Nicholas Sun Leah Bazik Star K. Huynh In-Jae Cho Tomasz Boczek Kun-Che Chang Noelia J. Kunzevitzky Jeffrey L. Goldberg
author_sort	Alexander Kreymerman
title	MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
title_short	MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
title_full	MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
title_fullStr	MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
title_full_unstemmed	MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
title_sort	mtp18 is a novel regulator of mitochondrial fission in cns neuron development, axonal growth, and injury responses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0215dae8fa5149f99d708b4117f0df14
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MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses

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