Structural basis of the activation of c-MET receptor

Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET...

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Autores principales:	Emiko Uchikawa, Zhiming Chen, Guan-Yu Xiao, Xuewu Zhang, Xiao-chen Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc
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id	oai:doaj.org-article:021c698d2144460ea3a9ccd0134764dc
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spelling	oai:doaj.org-article:021c698d2144460ea3a9ccd0134764dc2021-12-02T16:32:13ZStructural basis of the activation of c-MET receptor10.1038/s41467-021-24367-32041-1723https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24367-3https://doaj.org/toc/2041-1723Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.Emiko UchikawaZhiming ChenGuan-Yu XiaoXuewu ZhangXiao-chen BaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emiko Uchikawa Zhiming Chen Guan-Yu Xiao Xuewu Zhang Xiao-chen Bai Structural basis of the activation of c-MET receptor
description	Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.
format	article
author	Emiko Uchikawa Zhiming Chen Guan-Yu Xiao Xuewu Zhang Xiao-chen Bai
author_facet	Emiko Uchikawa Zhiming Chen Guan-Yu Xiao Xuewu Zhang Xiao-chen Bai
author_sort	Emiko Uchikawa
title	Structural basis of the activation of c-MET receptor
title_short	Structural basis of the activation of c-MET receptor
title_full	Structural basis of the activation of c-MET receptor
title_fullStr	Structural basis of the activation of c-MET receptor
title_full_unstemmed	Structural basis of the activation of c-MET receptor
title_sort	structural basis of the activation of c-met receptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc
work_keys_str_mv	AT emikouchikawa structuralbasisoftheactivationofcmetreceptor AT zhimingchen structuralbasisoftheactivationofcmetreceptor AT guanyuxiao structuralbasisoftheactivationofcmetreceptor AT xuewuzhang structuralbasisoftheactivationofcmetreceptor AT xiaochenbai structuralbasisoftheactivationofcmetreceptor
_version_	1718383792331161600

Structural basis of the activation of c-MET receptor

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