Structural basis of the activation of c-MET receptor

Structural basis of the activation of c-MET receptor

Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET...

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Main Authors: Emiko Uchikawa, Zhiming Chen, Guan-Yu Xiao, Xuewu Zhang, Xiao-chen Bai
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc
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spelling oai:doaj.org-article:021c698d2144460ea3a9ccd0134764dc2021-12-02T16:32:13ZStructural basis of the activation of c-MET receptor10.1038/s41467-021-24367-32041-1723https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24367-3https://doaj.org/toc/2041-1723Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.Emiko UchikawaZhiming ChenGuan-Yu XiaoXuewu ZhangXiao-chen BaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
Structural basis of the activation of c-MET receptor
description Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.
format article
author Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
author_facet Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
author_sort Emiko Uchikawa
title Structural basis of the activation of c-MET receptor
title_short Structural basis of the activation of c-MET receptor
title_full Structural basis of the activation of c-MET receptor
title_fullStr Structural basis of the activation of c-MET receptor
title_full_unstemmed Structural basis of the activation of c-MET receptor
title_sort structural basis of the activation of c-met receptor
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc
work_keys_str_mv AT emikouchikawa structuralbasisoftheactivationofcmetreceptor
AT zhimingchen structuralbasisoftheactivationofcmetreceptor
AT guanyuxiao structuralbasisoftheactivationofcmetreceptor
AT xuewuzhang structuralbasisoftheactivationofcmetreceptor
AT xiaochenbai structuralbasisoftheactivationofcmetreceptor
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