Structural basis of the activation of c-MET receptor

Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET...

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Autores principales: Emiko Uchikawa, Zhiming Chen, Guan-Yu Xiao, Xuewu Zhang, Xiao-chen Bai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/021c698d2144460ea3a9ccd0134764dc
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