Development of Synthetic DNA Circuit and Networks for Molecular Information Processing

Deoxyribonucleic acid (DNA), a genetic material, encodes all living information and living characteristics, e.g., in cell, DNA signaling circuits control the transcription activities of specific genes. In recent years, various DNA circuits have been developed to implement a wide range of signaling a...

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Autores principales:	Yongpeng Zhang, Yuhua Feng, Yuan Liang, Jing Yang, Cheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	synthetic DNA circuit DNA strand displacement DNA self-assembly DNA networks DNA computing Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0222492d8a7b417f88a6532cb3f5cef0
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spelling	oai:doaj.org-article:0222492d8a7b417f88a6532cb3f5cef02021-11-25T18:31:09ZDevelopment of Synthetic DNA Circuit and Networks for Molecular Information Processing10.3390/nano111129552079-4991https://doaj.org/article/0222492d8a7b417f88a6532cb3f5cef02021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2955https://doaj.org/toc/2079-4991Deoxyribonucleic acid (DNA), a genetic material, encodes all living information and living characteristics, e.g., in cell, DNA signaling circuits control the transcription activities of specific genes. In recent years, various DNA circuits have been developed to implement a wide range of signaling and for regulating gene network functions. In particular, a synthetic DNA circuit, with a programmable design and easy construction, has become a crucial method through which to simulate and regulate DNA signaling networks. Importantly, the construction of a hierarchical DNA circuit provides a useful tool for regulating gene networks and for processing molecular information. Moreover, via their robust and modular properties, DNA circuits can amplify weak signals and establish programmable cascade systems, which are particularly suitable for the applications of biosensing and detecting. Furthermore, a biological enzyme can also be used to provide diverse circuit regulation elements. Currently, studies regarding the mechanisms and applications of synthetic DNA circuit are important for the establishment of more advanced artificial gene regulation systems and intelligent molecular sensing tools. We therefore summarize recent relevant research progress, contributing to the development of nanotechnology-based synthetic DNA circuits. By summarizing the current highlights and the development of synthetic DNA circuits, this paper provides additional insights for future DNA circuit development and provides a foundation for the construction of more advanced DNA circuits.Yongpeng ZhangYuhua FengYuan LiangJing YangCheng ZhangMDPI AGarticlesynthetic DNA circuitDNA strand displacementDNA self-assemblyDNA networksDNA computingChemistryQD1-999ENNanomaterials, Vol 11, Iss 2955, p 2955 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	synthetic DNA circuit DNA strand displacement DNA self-assembly DNA networks DNA computing Chemistry QD1-999
spellingShingle	synthetic DNA circuit DNA strand displacement DNA self-assembly DNA networks DNA computing Chemistry QD1-999 Yongpeng Zhang Yuhua Feng Yuan Liang Jing Yang Cheng Zhang Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
description	Deoxyribonucleic acid (DNA), a genetic material, encodes all living information and living characteristics, e.g., in cell, DNA signaling circuits control the transcription activities of specific genes. In recent years, various DNA circuits have been developed to implement a wide range of signaling and for regulating gene network functions. In particular, a synthetic DNA circuit, with a programmable design and easy construction, has become a crucial method through which to simulate and regulate DNA signaling networks. Importantly, the construction of a hierarchical DNA circuit provides a useful tool for regulating gene networks and for processing molecular information. Moreover, via their robust and modular properties, DNA circuits can amplify weak signals and establish programmable cascade systems, which are particularly suitable for the applications of biosensing and detecting. Furthermore, a biological enzyme can also be used to provide diverse circuit regulation elements. Currently, studies regarding the mechanisms and applications of synthetic DNA circuit are important for the establishment of more advanced artificial gene regulation systems and intelligent molecular sensing tools. We therefore summarize recent relevant research progress, contributing to the development of nanotechnology-based synthetic DNA circuits. By summarizing the current highlights and the development of synthetic DNA circuits, this paper provides additional insights for future DNA circuit development and provides a foundation for the construction of more advanced DNA circuits.
format	article
author	Yongpeng Zhang Yuhua Feng Yuan Liang Jing Yang Cheng Zhang
author_facet	Yongpeng Zhang Yuhua Feng Yuan Liang Jing Yang Cheng Zhang
author_sort	Yongpeng Zhang
title	Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
title_short	Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
title_full	Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
title_fullStr	Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
title_full_unstemmed	Development of Synthetic DNA Circuit and Networks for Molecular Information Processing
title_sort	development of synthetic dna circuit and networks for molecular information processing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0222492d8a7b417f88a6532cb3f5cef0
work_keys_str_mv	AT yongpengzhang developmentofsyntheticdnacircuitandnetworksformolecularinformationprocessing AT yuhuafeng developmentofsyntheticdnacircuitandnetworksformolecularinformationprocessing AT yuanliang developmentofsyntheticdnacircuitandnetworksformolecularinformationprocessing AT jingyang developmentofsyntheticdnacircuitandnetworksformolecularinformationprocessing AT chengzhang developmentofsyntheticdnacircuitandnetworksformolecularinformationprocessing
_version_	1718410995075907584

Development of Synthetic DNA Circuit and Networks for Molecular Information Processing

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