The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes

The role of inflammation in the pathogenesis of depression is becoming increasingly apparent, but its role in perinatal depression is less well-studied. Pregnancy and the postpartum are characterised by distinct and changing inflammatory profiles throughout, which makes the study of depression-relat...

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Autor principal: Kristi M. Sawyer
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/0223eeaae86e4060afdfda9fb811e925
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spelling oai:doaj.org-article:0223eeaae86e4060afdfda9fb811e9252021-11-28T04:38:40ZThe role of inflammation in the pathogenesis of perinatal depression and offspring outcomes2666-354610.1016/j.bbih.2021.100390https://doaj.org/article/0223eeaae86e4060afdfda9fb811e9252021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666354621001939https://doaj.org/toc/2666-3546The role of inflammation in the pathogenesis of depression is becoming increasingly apparent, but its role in perinatal depression is less well-studied. Pregnancy and the postpartum are characterised by distinct and changing inflammatory profiles throughout, which makes the study of depression-related alterations in this period complex. This review presents literature discussing a role for the immune system in both antenatal and postnatal depression. Furthermore, literature investigating the role of the maternal immune system on breast milk composition and offspring immunological and behavioural outcomes is discussed, before concluding with suggestions for future work as this developing field grows.Kristi M. SawyerElsevierarticlePerinatalAntenatalPostnatalDepressionInflammationBreast milkNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100390- (2021)
institution DOAJ
collection DOAJ
language EN
topic Perinatal
Antenatal
Postnatal
Depression
Inflammation
Breast milk
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle Perinatal
Antenatal
Postnatal
Depression
Inflammation
Breast milk
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Kristi M. Sawyer
The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
description The role of inflammation in the pathogenesis of depression is becoming increasingly apparent, but its role in perinatal depression is less well-studied. Pregnancy and the postpartum are characterised by distinct and changing inflammatory profiles throughout, which makes the study of depression-related alterations in this period complex. This review presents literature discussing a role for the immune system in both antenatal and postnatal depression. Furthermore, literature investigating the role of the maternal immune system on breast milk composition and offspring immunological and behavioural outcomes is discussed, before concluding with suggestions for future work as this developing field grows.
format article
author Kristi M. Sawyer
author_facet Kristi M. Sawyer
author_sort Kristi M. Sawyer
title The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
title_short The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
title_full The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
title_fullStr The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
title_full_unstemmed The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
title_sort role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
publisher Elsevier
publishDate 2021
url https://doaj.org/article/0223eeaae86e4060afdfda9fb811e925
work_keys_str_mv AT kristimsawyer theroleofinflammationinthepathogenesisofperinataldepressionandoffspringoutcomes
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