Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride
Abstract Pruritus is known to be a common complication in hepatitis patients, but the exact frequency and degree are not fully elucidated. Thus, we evaluated pruritus of 450 patients with chronic liver disease at our hospital. Pruritus was observed in 240 (53%) of the patients. Pruritus was signific...
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2021
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oai:doaj.org-article:022457205d40407a922e1172f2dfdefa2021-12-02T14:06:50ZPruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride10.1038/s41598-021-82566-w2045-2322https://doaj.org/article/022457205d40407a922e1172f2dfdefa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82566-whttps://doaj.org/toc/2045-2322Abstract Pruritus is known to be a common complication in hepatitis patients, but the exact frequency and degree are not fully elucidated. Thus, we evaluated pruritus of 450 patients with chronic liver disease at our hospital. Pruritus was observed in 240 (53%) of the patients. Pruritus was significantly associated with males (OR = 1.51, P = 0.038) and patients with alkaline phosphatase (ALP) ≥ 200 U/L (OR = 1.56, P = 0.0495) and was significantly less in HBsAg-positive patients (OR = 0.449, P = 0.004). Seasonally, there was no difference in the frequency of pruritus between summer and winter. Of the 24 refractory pruritus patients treated with nalfurafine, 17 (71%) indicated improvement of itch, which is defined as a decrease in the visual analog scale score ≥ 30 mm. Pruritus was improved by nalfurafine both during daytime and nighttime in the Kawashima’s scores evaluation. All patients who received nalfurafine exhibited improved Kawashima’s scores ≥ 1 point during the daytime or nighttime. In conclusion, pruritus occurred in > 50% of patients with chronic liver disease, and predictors of pruritus were males and ALP ≥ 200 U/L. Nalfurafine may be useful for pruritus, regardless of whether daytime or nighttime.Shuhei YoshikawaTakeharu AsanoMina MorinoKeita MatsumotoHitomi KashimaYudai KoitoTakaya MiuraYuko TakahashiRumiko TsuboiTakehiro IshiiHaruka OtakeJunichi FujiwaraMasanari SekineTakeshi UeharaKazuhito YuhashiSatohiro MatsumotoShinichi AsabeHiroyuki MiyataniHirosato MashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Shuhei Yoshikawa Takeharu Asano Mina Morino Keita Matsumoto Hitomi Kashima Yudai Koito Takaya Miura Yuko Takahashi Rumiko Tsuboi Takehiro Ishii Haruka Otake Junichi Fujiwara Masanari Sekine Takeshi Uehara Kazuhito Yuhashi Satohiro Matsumoto Shinichi Asabe Hiroyuki Miyatani Hirosato Mashima Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| description |
Abstract Pruritus is known to be a common complication in hepatitis patients, but the exact frequency and degree are not fully elucidated. Thus, we evaluated pruritus of 450 patients with chronic liver disease at our hospital. Pruritus was observed in 240 (53%) of the patients. Pruritus was significantly associated with males (OR = 1.51, P = 0.038) and patients with alkaline phosphatase (ALP) ≥ 200 U/L (OR = 1.56, P = 0.0495) and was significantly less in HBsAg-positive patients (OR = 0.449, P = 0.004). Seasonally, there was no difference in the frequency of pruritus between summer and winter. Of the 24 refractory pruritus patients treated with nalfurafine, 17 (71%) indicated improvement of itch, which is defined as a decrease in the visual analog scale score ≥ 30 mm. Pruritus was improved by nalfurafine both during daytime and nighttime in the Kawashima’s scores evaluation. All patients who received nalfurafine exhibited improved Kawashima’s scores ≥ 1 point during the daytime or nighttime. In conclusion, pruritus occurred in > 50% of patients with chronic liver disease, and predictors of pruritus were males and ALP ≥ 200 U/L. Nalfurafine may be useful for pruritus, regardless of whether daytime or nighttime. |
| format |
article |
| author |
Shuhei Yoshikawa Takeharu Asano Mina Morino Keita Matsumoto Hitomi Kashima Yudai Koito Takaya Miura Yuko Takahashi Rumiko Tsuboi Takehiro Ishii Haruka Otake Junichi Fujiwara Masanari Sekine Takeshi Uehara Kazuhito Yuhashi Satohiro Matsumoto Shinichi Asabe Hiroyuki Miyatani Hirosato Mashima |
| author_facet |
Shuhei Yoshikawa Takeharu Asano Mina Morino Keita Matsumoto Hitomi Kashima Yudai Koito Takaya Miura Yuko Takahashi Rumiko Tsuboi Takehiro Ishii Haruka Otake Junichi Fujiwara Masanari Sekine Takeshi Uehara Kazuhito Yuhashi Satohiro Matsumoto Shinichi Asabe Hiroyuki Miyatani Hirosato Mashima |
| author_sort |
Shuhei Yoshikawa |
| title |
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| title_short |
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| title_full |
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| title_fullStr |
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| title_full_unstemmed |
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| title_sort |
pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/022457205d40407a922e1172f2dfdefa |
| work_keys_str_mv |
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