Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts

In recent decades, extensive research has been focused on the screening and investigating the antioxidant and anticancer activities of medicinal plants extracts or isolated natural product-based drugs. Therefore, the present study aimed to evaluate the phytochemical, antioxidant and in vitro antican...

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Autores principales:	Mounir Tilaoui, Hanane Achibat, Marius Lébri, Stéphanie Lagou, Hassan Ait Mouse, Sofia Zazouli, Abderrafia Hafid, Abdelmajid Zyad, Mostafa Khouili
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	bombax buonopozense phytochemical screening antioxidant activity cancer Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/022633e14bd64c55b0fea11cf81f4028
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spelling	oai:doaj.org-article:022633e14bd64c55b0fea11cf81f40282021-11-26T11:19:47ZPhytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts1310-28181314-353010.1080/13102818.2021.1997156https://doaj.org/article/022633e14bd64c55b0fea11cf81f40282021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13102818.2021.1997156https://doaj.org/toc/1310-2818https://doaj.org/toc/1314-3530In recent decades, extensive research has been focused on the screening and investigating the antioxidant and anticancer activities of medicinal plants extracts or isolated natural product-based drugs. Therefore, the present study aimed to evaluate the phytochemical, antioxidant and in vitro anticancer activities of Bombax buonopozense extracts. Standard methods were used for the identification of alkaloids, tannins, flavonoids, coumarins, saponins, sterol, triterpenes and reducing compounds. Free-radical–scavenging activity was measured by the 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and the cytotoxic potential was evaluated in the P815 murin lymphoblast-like mastocytoma cell line using the MTT assay. Regarding the antioxidant activity, our results showed a powerful in vitro free-radical scavenging activity of the ethanolic extract compared to the aqueous extracts, with IC50 values of 10 and 220 µg/mL, respectively. In the MTT assay, the ethanolic extract showed a moderate and dose-dependent association growth inhibition of P815 cells in a dose above of 200 µg/mL with IC50 of 74 µg/mL compared to cisplatin (IC50= 4 µg/mL). Our findings demonstrate that Bombax buonopozense ethanolic extract could be an effective antioxidant and promising antiproliferative agent.Mounir TilaouiHanane AchibatMarius LébriStéphanie LagouHassan Ait MouseSofia ZazouliAbderrafia HafidAbdelmajid ZyadMostafa KhouiliTaylor & Francis Grouparticle bombax buonopozense phytochemical screeningantioxidant activitycancerBiotechnologyTP248.13-248.65ENBiotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1662-1668 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bombax buonopozense phytochemical screening antioxidant activity cancer Biotechnology TP248.13-248.65
spellingShingle	bombax buonopozense phytochemical screening antioxidant activity cancer Biotechnology TP248.13-248.65 Mounir Tilaoui Hanane Achibat Marius Lébri Stéphanie Lagou Hassan Ait Mouse Sofia Zazouli Abderrafia Hafid Abdelmajid Zyad Mostafa Khouili Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
description	In recent decades, extensive research has been focused on the screening and investigating the antioxidant and anticancer activities of medicinal plants extracts or isolated natural product-based drugs. Therefore, the present study aimed to evaluate the phytochemical, antioxidant and in vitro anticancer activities of Bombax buonopozense extracts. Standard methods were used for the identification of alkaloids, tannins, flavonoids, coumarins, saponins, sterol, triterpenes and reducing compounds. Free-radical–scavenging activity was measured by the 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, and the cytotoxic potential was evaluated in the P815 murin lymphoblast-like mastocytoma cell line using the MTT assay. Regarding the antioxidant activity, our results showed a powerful in vitro free-radical scavenging activity of the ethanolic extract compared to the aqueous extracts, with IC50 values of 10 and 220 µg/mL, respectively. In the MTT assay, the ethanolic extract showed a moderate and dose-dependent association growth inhibition of P815 cells in a dose above of 200 µg/mL with IC50 of 74 µg/mL compared to cisplatin (IC50= 4 µg/mL). Our findings demonstrate that Bombax buonopozense ethanolic extract could be an effective antioxidant and promising antiproliferative agent.
format	article
author	Mounir Tilaoui Hanane Achibat Marius Lébri Stéphanie Lagou Hassan Ait Mouse Sofia Zazouli Abderrafia Hafid Abdelmajid Zyad Mostafa Khouili
author_facet	Mounir Tilaoui Hanane Achibat Marius Lébri Stéphanie Lagou Hassan Ait Mouse Sofia Zazouli Abderrafia Hafid Abdelmajid Zyad Mostafa Khouili
author_sort	Mounir Tilaoui
title	Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
title_short	Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
title_full	Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
title_fullStr	Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
title_full_unstemmed	Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
title_sort	phytochemical screening, antioxidant and in vitro anticancer activities of bombax buonopozense stem bark extracts
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/022633e14bd64c55b0fea11cf81f4028
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Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts

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