G3BP1 controls the senescence-associated secretome and its impact on cancer progression

The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP secretion is a primary mediator of senescence-asso...

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Autores principales:	Amr Omer, Monica Cruz Barrera, Julian L. Moran, Xian J. Lian, Sergio Di Marco, Christian Beausejour, Imed-Eddine Gallouzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02292b1787c3465190c76cee31b72257
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id	oai:doaj.org-article:02292b1787c3465190c76cee31b72257
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spelling	oai:doaj.org-article:02292b1787c3465190c76cee31b722572021-12-02T17:13:19ZG3BP1 controls the senescence-associated secretome and its impact on cancer progression10.1038/s41467-020-18734-92041-1723https://doaj.org/article/02292b1787c3465190c76cee31b722572020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18734-9https://doaj.org/toc/2041-1723The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP secretion is a primary mediator of senescence-associated tumour growth.Amr OmerMonica Cruz BarreraJulian L. MoranXian J. LianSergio Di MarcoChristian BeausejourImed-Eddine GallouziNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amr Omer Monica Cruz Barrera Julian L. Moran Xian J. Lian Sergio Di Marco Christian Beausejour Imed-Eddine Gallouzi G3BP1 controls the senescence-associated secretome and its impact on cancer progression
description	The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP secretion is a primary mediator of senescence-associated tumour growth.
format	article
author	Amr Omer Monica Cruz Barrera Julian L. Moran Xian J. Lian Sergio Di Marco Christian Beausejour Imed-Eddine Gallouzi
author_facet	Amr Omer Monica Cruz Barrera Julian L. Moran Xian J. Lian Sergio Di Marco Christian Beausejour Imed-Eddine Gallouzi
author_sort	Amr Omer
title	G3BP1 controls the senescence-associated secretome and its impact on cancer progression
title_short	G3BP1 controls the senescence-associated secretome and its impact on cancer progression
title_full	G3BP1 controls the senescence-associated secretome and its impact on cancer progression
title_fullStr	G3BP1 controls the senescence-associated secretome and its impact on cancer progression
title_full_unstemmed	G3BP1 controls the senescence-associated secretome and its impact on cancer progression
title_sort	g3bp1 controls the senescence-associated secretome and its impact on cancer progression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02292b1787c3465190c76cee31b72257
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G3BP1 controls the senescence-associated secretome and its impact on cancer progression

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