Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.

<h4>Background</h4>Humans have a widely different diet from other primate species, and are dependent on its high nutritional content. The molecular mechanisms responsible for adaptation to the human diet are currently unknown. Here, we addressed this question by investigating whether the...

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Autores principales:	Kai Weng, Haiyang Hu, Augix Guohua Xu, Philipp Khaitovich, Mehmet Somel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0229f4d15e144f998716bf8c49016c0a
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spelling	oai:doaj.org-article:0229f4d15e144f998716bf8c49016c0a2021-11-18T07:07:39ZMechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.1932-620310.1371/journal.pone.0043915https://doaj.org/article/0229f4d15e144f998716bf8c49016c0a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937124/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Humans have a widely different diet from other primate species, and are dependent on its high nutritional content. The molecular mechanisms responsible for adaptation to the human diet are currently unknown. Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees.<h4>Results</h4>Using mouse and primate transcriptomic data, we identified the transcription factor EGR1 (early growth response 1) as a putative regulator of diet-related differential gene expression between human and chimpanzee livers. Specifically, we predict that EGR1 regulates the response to the high caloric content of human diets. However, we also show that close to 90% of the dietary response to the primate diet found in mice, is not observed in primates. This might be explained by changes in tissue-specific gene expression between taxa.<h4>Conclusion</h4>Our results suggest that the gene expression response to the nutritionally rich human diet is partially mediated by the transcription factor EGR1. While this EGR1-driven response is conserved between mice and primates, the bulk of the mouse response to human and chimpanzee dietary differences is not observed in primates. This result highlights the rapid evolution of diet-related expression regulation and underscores potential limitations of mouse models in dietary studies.Kai WengHaiyang HuAugix Guohua XuPhilipp KhaitovichMehmet SomelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43915 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Weng Haiyang Hu Augix Guohua Xu Philipp Khaitovich Mehmet Somel Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
description	<h4>Background</h4>Humans have a widely different diet from other primate species, and are dependent on its high nutritional content. The molecular mechanisms responsible for adaptation to the human diet are currently unknown. Here, we addressed this question by investigating whether the gene expression response observed in mice fed human and chimpanzee diets involves the same regulatory mechanisms as expression differences between humans and chimpanzees.<h4>Results</h4>Using mouse and primate transcriptomic data, we identified the transcription factor EGR1 (early growth response 1) as a putative regulator of diet-related differential gene expression between human and chimpanzee livers. Specifically, we predict that EGR1 regulates the response to the high caloric content of human diets. However, we also show that close to 90% of the dietary response to the primate diet found in mice, is not observed in primates. This might be explained by changes in tissue-specific gene expression between taxa.<h4>Conclusion</h4>Our results suggest that the gene expression response to the nutritionally rich human diet is partially mediated by the transcription factor EGR1. While this EGR1-driven response is conserved between mice and primates, the bulk of the mouse response to human and chimpanzee dietary differences is not observed in primates. This result highlights the rapid evolution of diet-related expression regulation and underscores potential limitations of mouse models in dietary studies.
format	article
author	Kai Weng Haiyang Hu Augix Guohua Xu Philipp Khaitovich Mehmet Somel
author_facet	Kai Weng Haiyang Hu Augix Guohua Xu Philipp Khaitovich Mehmet Somel
author_sort	Kai Weng
title	Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
title_short	Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
title_full	Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
title_fullStr	Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
title_full_unstemmed	Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.
title_sort	mechanisms of dietary response in mice and primates: a role for egr1 in regulating the reaction to human-specific nutritional content.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0229f4d15e144f998716bf8c49016c0a
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Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content.

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