A metal-based inhibitor of NEDD8-activating enzyme.

A cyclometallated rhodium(III) complex [Rh(ppy)(2)(dppz)](+) (1) (where ppy=2-phenylpyridine and dppz=dipyrido[3,2-a:2',3'-c]phenazine dipyridophenazine) has been prepared and identified as an inhibitor of NEDD8-activating enzyme (NAE). The complex inhibited NAE activity in cell-free and c...

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Autores principales: Hai-Jing Zhong, Hui Yang, Daniel Shiu-Hin Chan, Chung-Hang Leung, Hui-Min Wang, Dik-Lung Ma
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/022f413bb4b34c8cb60da3d86a5c59c9
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