A realistic validation study of a new nitrogen multiple-breath washout system.

<h4>Background</h4>For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the assessment of a new nitrogen (N(2))MBW system.<...

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Autores principales:	Florian Singer, Birgitta Houltz, Philipp Latzin, Paul Robinson, Per Gustafsson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/022fbdda970f43ae828e1edddd41b2f2
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spelling	oai:doaj.org-article:022fbdda970f43ae828e1edddd41b2f22021-11-18T07:20:26ZA realistic validation study of a new nitrogen multiple-breath washout system.1932-620310.1371/journal.pone.0036083https://doaj.org/article/022fbdda970f43ae828e1edddd41b2f22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558338/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the assessment of a new nitrogen (N(2))MBW system.<h4>Methods</h4>The N(2)MBW setup indirectly measures the N(2) fraction (F(N2)) from main-stream carbon dioxide (CO(2)) and side-stream oxygen (O(2)) signals: F(N2) = 1-F(O2)-F(CO2)-F(Argon). For in vitro N(2)MBW, a double chamber plastic lung model was filled with water, heated to 37°C, and ventilated at various lung volumes, respiratory rates, and F(CO2). In vivo N(2)MBW was undertaken in triplets on two occasions in 30 healthy adults. Primary N(2)MBW outcome was functional residual capacity (FRC). We assessed in vitro error (√[difference](2)) between measured and model FRC (100-4174 mL), and error between tests of in vivo FRC, lung clearance index (LCI), and normalized phase III slope indices (S(acin) and S(cond)).<h4>Results</h4>The model generated 145 FRCs under BTPS conditions and various breathing patterns. Mean (SD) error was 2.3 (1.7)%. In 500 to 4174 mL FRCs, 121 (98%) of FRCs were within 5%. In 100 to 400 mL FRCs, the error was better than 7%. In vivo FRC error between tests was 10.1 (8.2)%. LCI was the most reproducible ventilation inhomogeneity index.<h4>Conclusion</h4>The lung model generates lung volumes under the conditions encountered during clinical MBW testing and enables realistic validation of MBW systems. The new N(2)MBW system reliably measures lung volumes and delivers reproducible LCI values.Florian SingerBirgitta HoultzPhilipp LatzinPaul RobinsonPer GustafssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e36083 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florian Singer Birgitta Houltz Philipp Latzin Paul Robinson Per Gustafsson A realistic validation study of a new nitrogen multiple-breath washout system.
description	<h4>Background</h4>For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the assessment of a new nitrogen (N(2))MBW system.<h4>Methods</h4>The N(2)MBW setup indirectly measures the N(2) fraction (F(N2)) from main-stream carbon dioxide (CO(2)) and side-stream oxygen (O(2)) signals: F(N2) = 1-F(O2)-F(CO2)-F(Argon). For in vitro N(2)MBW, a double chamber plastic lung model was filled with water, heated to 37°C, and ventilated at various lung volumes, respiratory rates, and F(CO2). In vivo N(2)MBW was undertaken in triplets on two occasions in 30 healthy adults. Primary N(2)MBW outcome was functional residual capacity (FRC). We assessed in vitro error (√[difference](2)) between measured and model FRC (100-4174 mL), and error between tests of in vivo FRC, lung clearance index (LCI), and normalized phase III slope indices (S(acin) and S(cond)).<h4>Results</h4>The model generated 145 FRCs under BTPS conditions and various breathing patterns. Mean (SD) error was 2.3 (1.7)%. In 500 to 4174 mL FRCs, 121 (98%) of FRCs were within 5%. In 100 to 400 mL FRCs, the error was better than 7%. In vivo FRC error between tests was 10.1 (8.2)%. LCI was the most reproducible ventilation inhomogeneity index.<h4>Conclusion</h4>The lung model generates lung volumes under the conditions encountered during clinical MBW testing and enables realistic validation of MBW systems. The new N(2)MBW system reliably measures lung volumes and delivers reproducible LCI values.
format	article
author	Florian Singer Birgitta Houltz Philipp Latzin Paul Robinson Per Gustafsson
author_facet	Florian Singer Birgitta Houltz Philipp Latzin Paul Robinson Per Gustafsson
author_sort	Florian Singer
title	A realistic validation study of a new nitrogen multiple-breath washout system.
title_short	A realistic validation study of a new nitrogen multiple-breath washout system.
title_full	A realistic validation study of a new nitrogen multiple-breath washout system.
title_fullStr	A realistic validation study of a new nitrogen multiple-breath washout system.
title_full_unstemmed	A realistic validation study of a new nitrogen multiple-breath washout system.
title_sort	realistic validation study of a new nitrogen multiple-breath washout system.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/022fbdda970f43ae828e1edddd41b2f2
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A realistic validation study of a new nitrogen multiple-breath washout system.

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