Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma

Tomoko Naito,1 Keiji Yoshikawa,2 Shiro Mizoue,3 Mami Nanno,4 Tairo Kimura,5 Hirotaka Suzumura,6 Ryuji Takeda,7 Fumio Shiraga1 1Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, 2Yoshikawa Eye Clinic, Tokyo, 3Department of Ophthalmology, Ehime University Graduate...

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Autores principales:	Naito T, Yoshikawa K, Mizoue S, Nanno M, Kimura T, Suzumura H, Takeda R, Shiraga F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/023298f3de94434ab86856bb9cf950b4
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spelling	oai:doaj.org-article:023298f3de94434ab86856bb9cf950b42021-12-02T03:30:38ZRelationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma1177-5483https://doaj.org/article/023298f3de94434ab86856bb9cf950b42015-11-01T00:00:00Zhttps://www.dovepress.com/relationship-between-consecutive-deterioration-of-mean-deviation-value-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tomoko Naito,1 Keiji Yoshikawa,2 Shiro Mizoue,3 Mami Nanno,4 Tairo Kimura,5 Hirotaka Suzumura,6 Ryuji Takeda,7 Fumio Shiraga1 1Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, 2Yoshikawa Eye Clinic, Tokyo, 3Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, 4Kagurazaka Minamino Eye Clinic, 5Ueno Eye Clinic, 6Suzumura Eye Clinic, Tokyo, 7Department of Agriculture, Kinki University, Nara, Japan Purpose: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma.Patients and methods: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed.Results: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01).Conclusion: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG. Keywords: primary open-angle glaucoma, normal tension glaucoma, visual field progression, mean deviation value, consecutive deterioration, mean deviation slope, Humphrey field analyzerNaito TYoshikawa KMizoue SNanno MKimura TSuzumura HTakeda RShiraga FDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 2217-2222 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Naito T Yoshikawa K Mizoue S Nanno M Kimura T Suzumura H Takeda R Shiraga F Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
description	Tomoko Naito,1 Keiji Yoshikawa,2 Shiro Mizoue,3 Mami Nanno,4 Tairo Kimura,5 Hirotaka Suzumura,6 Ryuji Takeda,7 Fumio Shiraga1 1Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, 2Yoshikawa Eye Clinic, Tokyo, 3Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, 4Kagurazaka Minamino Eye Clinic, 5Ueno Eye Clinic, 6Suzumura Eye Clinic, Tokyo, 7Department of Agriculture, Kinki University, Nara, Japan Purpose: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma.Patients and methods: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed.Results: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01).Conclusion: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG. Keywords: primary open-angle glaucoma, normal tension glaucoma, visual field progression, mean deviation value, consecutive deterioration, mean deviation slope, Humphrey field analyzer
format	article
author	Naito T Yoshikawa K Mizoue S Nanno M Kimura T Suzumura H Takeda R Shiraga F
author_facet	Naito T Yoshikawa K Mizoue S Nanno M Kimura T Suzumura H Takeda R Shiraga F
author_sort	Naito T
title	Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_short	Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_full	Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_fullStr	Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_full_unstemmed	Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_sort	relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/023298f3de94434ab86856bb9cf950b4
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Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma

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