Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry

Abstract In eye movement perimetry (EMP), the saccadic reaction time (SRT) to ‘seen’ visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in eva...

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Main Authors:	Deepmala Mazumdar, Najiya S. Kadavath Meethal, Ronnie George, Johan J. M. Pel
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/02336e9a71a34e0da29d704e43f30cf0
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spelling	oai:doaj.org-article:02336e9a71a34e0da29d704e43f30cf02021-12-02T14:16:06ZSaccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry10.1038/s41598-021-81762-y2045-2322https://doaj.org/article/02336e9a71a34e0da29d704e43f30cf02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81762-yhttps://doaj.org/toc/2045-2322Abstract In eye movement perimetry (EMP), the saccadic reaction time (SRT) to ‘seen’ visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 healthy subjects and 30 glaucoma patients were recruited prospectively. The SRTs were used to calculate the normative limits within 5 predefined hemi-field sectors. Scores were assigned to probabilities for SRT at the level of 5%, 2.5% 1% and 0.5%. Per sector pair, a probability score limit (PSL) was calculated at each of the four levels and were compared with the scores obtained from the test cohort. The classification accuracy ‘normal versus abnormal’ was assessed for PSL in EMP and compared with glaucoma hemi-field test in standard automated perimetry. We found no statistically significant differences in SRTs between the mirror sectors in healthy subjects. The PSL at 2.5% had moderate classification accuracy with a specificity of 77% and sensitivity 70%. This could be suggestive of an SRT delay in the overall visual field in glaucoma.Deepmala MazumdarNajiya S. Kadavath MeethalRonnie GeorgeJohan J. M. PelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deepmala Mazumdar Najiya S. Kadavath Meethal Ronnie George Johan J. M. Pel Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
description	Abstract In eye movement perimetry (EMP), the saccadic reaction time (SRT) to ‘seen’ visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 healthy subjects and 30 glaucoma patients were recruited prospectively. The SRTs were used to calculate the normative limits within 5 predefined hemi-field sectors. Scores were assigned to probabilities for SRT at the level of 5%, 2.5% 1% and 0.5%. Per sector pair, a probability score limit (PSL) was calculated at each of the four levels and were compared with the scores obtained from the test cohort. The classification accuracy ‘normal versus abnormal’ was assessed for PSL in EMP and compared with glaucoma hemi-field test in standard automated perimetry. We found no statistically significant differences in SRTs between the mirror sectors in healthy subjects. The PSL at 2.5% had moderate classification accuracy with a specificity of 77% and sensitivity 70%. This could be suggestive of an SRT delay in the overall visual field in glaucoma.
format	article
author	Deepmala Mazumdar Najiya S. Kadavath Meethal Ronnie George Johan J. M. Pel
author_facet	Deepmala Mazumdar Najiya S. Kadavath Meethal Ronnie George Johan J. M. Pel
author_sort	Deepmala Mazumdar
title	Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
title_short	Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
title_full	Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
title_fullStr	Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
title_full_unstemmed	Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
title_sort	saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02336e9a71a34e0da29d704e43f30cf0
work_keys_str_mv	AT deepmalamazumdar saccadicreactiontimeinmirrorimagesectorsacrosshorizontalmeridianineyemovementperimetry AT najiyaskadavathmeethal saccadicreactiontimeinmirrorimagesectorsacrosshorizontalmeridianineyemovementperimetry AT ronniegeorge saccadicreactiontimeinmirrorimagesectorsacrosshorizontalmeridianineyemovementperimetry AT johanjmpel saccadicreactiontimeinmirrorimagesectorsacrosshorizontalmeridianineyemovementperimetry
_version_	1718391704272240640

Saccadic reaction time in mirror image sectors across horizontal meridian in eye movement perimetry

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