Fullerene–biomolecule conjugates and their biomedicinal applications
Xinlin Yang,1 Ali Ebrahimi,1 Jie Li,1,2 Quanjun Cui11Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA; 2School of Materials Science, Beijing Institute of Technology, Beijing, People's Republic of ChinaAbs...
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Dove Medical Press
2013
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oai:doaj.org-article:0236ac020fc14fb2b66a675b36daaf642021-12-02T00:12:15ZFullerene–biomolecule conjugates and their biomedicinal applications1178-2013https://doaj.org/article/0236ac020fc14fb2b66a675b36daaf642013-12-01T00:00:00Zhttp://www.dovepress.com/fullerenendashbiomolecule-conjugates-and-their-biomedicinal-applicatio-a15332https://doaj.org/toc/1178-2013 Xinlin Yang,1 Ali Ebrahimi,1 Jie Li,1,2 Quanjun Cui11Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA; 2School of Materials Science, Beijing Institute of Technology, Beijing, People's Republic of ChinaAbstract: Fullerenes are among the strongest antioxidants and are characterized as "radical sponges." The research on biomedicinal applications of fullerenes has achieved significant progress since the landmark publication by Friedman et al in 1993. Fullerene–biomolecule conjugates have become an important area of research during the past 2 decades. By a thorough literature search, we attempt to update the information about the synthesis of different types of fullerene–biomolecule conjugates, including fullerene-containing amino acids and peptides, oligonucleotides, sugars, and esters. Moreover, we also discuss in this review recently reported data on the biological and pharmaceutical utilities of these compounds and some other fullerene derivatives of biomedical importance. While within the fullerene–biomolecule conjugates, in which fullerene may act as both an antioxidant and a carrier, specific targeting biomolecules conjugated to fullerene will undoubtedly strengthen the delivery of functional fullerenes to sites of clinical interest.Keywords: fullerene, amino acid, peptide, oligonucleotide, sugar, esterYang XEbrahimi ALi JCui QDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 77-92 (2013) |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Yang X Ebrahimi A Li J Cui Q Fullerene–biomolecule conjugates and their biomedicinal applications |
| description |
Xinlin Yang,1 Ali Ebrahimi,1 Jie Li,1,2 Quanjun Cui11Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA; 2School of Materials Science, Beijing Institute of Technology, Beijing, People's Republic of ChinaAbstract: Fullerenes are among the strongest antioxidants and are characterized as "radical sponges." The research on biomedicinal applications of fullerenes has achieved significant progress since the landmark publication by Friedman et al in 1993. Fullerene–biomolecule conjugates have become an important area of research during the past 2 decades. By a thorough literature search, we attempt to update the information about the synthesis of different types of fullerene–biomolecule conjugates, including fullerene-containing amino acids and peptides, oligonucleotides, sugars, and esters. Moreover, we also discuss in this review recently reported data on the biological and pharmaceutical utilities of these compounds and some other fullerene derivatives of biomedical importance. While within the fullerene–biomolecule conjugates, in which fullerene may act as both an antioxidant and a carrier, specific targeting biomolecules conjugated to fullerene will undoubtedly strengthen the delivery of functional fullerenes to sites of clinical interest.Keywords: fullerene, amino acid, peptide, oligonucleotide, sugar, ester |
| format |
article |
| author |
Yang X Ebrahimi A Li J Cui Q |
| author_facet |
Yang X Ebrahimi A Li J Cui Q |
| author_sort |
Yang X |
| title |
Fullerene–biomolecule conjugates and their biomedicinal applications |
| title_short |
Fullerene–biomolecule conjugates and their biomedicinal applications |
| title_full |
Fullerene–biomolecule conjugates and their biomedicinal applications |
| title_fullStr |
Fullerene–biomolecule conjugates and their biomedicinal applications |
| title_full_unstemmed |
Fullerene–biomolecule conjugates and their biomedicinal applications |
| title_sort |
fullerene–biomolecule conjugates and their biomedicinal applications |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/0236ac020fc14fb2b66a675b36daaf64 |
| work_keys_str_mv |
AT yangx fullerenendashbiomoleculeconjugatesandtheirbiomedicinalapplications AT ebrahimia fullerenendashbiomoleculeconjugatesandtheirbiomedicinalapplications AT lij fullerenendashbiomoleculeconjugatesandtheirbiomedicinalapplications AT cuiq fullerenendashbiomoleculeconjugatesandtheirbiomedicinalapplications |
| _version_ |
1718403843036807168 |