A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt

Abstract Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio...

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Autores principales:	Shiwei Li, Hongcai Wang, Feng Li, Maosong Chen, Pandi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0236e8d2737f406d8e8cedf8f49c0a38
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spelling	oai:doaj.org-article:0236e8d2737f406d8e8cedf8f49c0a382021-12-02T18:18:51ZA new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt10.1038/s41598-021-93315-42045-2322https://doaj.org/article/0236e8d2737f406d8e8cedf8f49c0a382021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93315-4https://doaj.org/toc/2045-2322Abstract Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio (NLRR) and DICH secondary to VP shunt. We performed a retrospective review of patients who underwent VP shunt between January 2016 and June 2020. Multivariable logistic regression analysis was used to assess the association of DICH and NLRR. Then patients were divided into two groups according to the optimal cut-off point of NLRR, propensity score matching (PSM) method was performed to reconfirm the result. A total of 130 patients were enrolled and DICH occurred in 29 patients. Elevated NLRR and history of craniotomy were independent risk factors for DICH secondary to VP shunt. The optimal cut off point of NLRR was 2.05, and the sensitivity was 89.7%, the specificity was 63.4%. Patients with NLRR > 2.05 had much higher incidence of DICH (40.6% vs 4.5%). Our finding suggested that DICH following VP shunt was not a rare complication and elevated NLRR could independently predict DICH. Inflammatory responses might play an important role in the development of DICH following VP shunt.Shiwei LiHongcai WangFeng LiMaosong ChenPandi ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiwei Li Hongcai Wang Feng Li Maosong Chen Pandi Chen A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
description	Abstract Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio (NLRR) and DICH secondary to VP shunt. We performed a retrospective review of patients who underwent VP shunt between January 2016 and June 2020. Multivariable logistic regression analysis was used to assess the association of DICH and NLRR. Then patients were divided into two groups according to the optimal cut-off point of NLRR, propensity score matching (PSM) method was performed to reconfirm the result. A total of 130 patients were enrolled and DICH occurred in 29 patients. Elevated NLRR and history of craniotomy were independent risk factors for DICH secondary to VP shunt. The optimal cut off point of NLRR was 2.05, and the sensitivity was 89.7%, the specificity was 63.4%. Patients with NLRR > 2.05 had much higher incidence of DICH (40.6% vs 4.5%). Our finding suggested that DICH following VP shunt was not a rare complication and elevated NLRR could independently predict DICH. Inflammatory responses might play an important role in the development of DICH following VP shunt.
format	article
author	Shiwei Li Hongcai Wang Feng Li Maosong Chen Pandi Chen
author_facet	Shiwei Li Hongcai Wang Feng Li Maosong Chen Pandi Chen
author_sort	Shiwei Li
title	A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_short	A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_full	A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_fullStr	A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_full_unstemmed	A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_sort	new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0236e8d2737f406d8e8cedf8f49c0a38
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A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt

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