Identification of modified peptides using localization-aware open search

Mass spectrometry-based proteomics is the method of choice for the global mapping of post-translational modifications, but matching and scoring peaks with unknown masses remains challenging. Here, the authors present a refined open search strategy to score all peaks with higher sensitivity and accur...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fengchao Yu, Guo Ci Teo, Andy T. Kong, Sarah E. Haynes, Dmitry M. Avtonomov, Daniel J. Geiszler, Alexey I. Nesvizhskii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02387a43c32348a9b61aa02e3a3e2a42
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02387a43c32348a9b61aa02e3a3e2a42
record_format	dspace
spelling	oai:doaj.org-article:02387a43c32348a9b61aa02e3a3e2a422021-12-02T18:51:02ZIdentification of modified peptides using localization-aware open search10.1038/s41467-020-17921-y2041-1723https://doaj.org/article/02387a43c32348a9b61aa02e3a3e2a422020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17921-yhttps://doaj.org/toc/2041-1723Mass spectrometry-based proteomics is the method of choice for the global mapping of post-translational modifications, but matching and scoring peaks with unknown masses remains challenging. Here, the authors present a refined open search strategy to score all peaks with higher sensitivity and accuracy.Fengchao YuGuo Ci TeoAndy T. KongSarah E. HaynesDmitry M. AvtonomovDaniel J. GeiszlerAlexey I. NesvizhskiiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fengchao Yu Guo Ci Teo Andy T. Kong Sarah E. Haynes Dmitry M. Avtonomov Daniel J. Geiszler Alexey I. Nesvizhskii Identification of modified peptides using localization-aware open search
description	Mass spectrometry-based proteomics is the method of choice for the global mapping of post-translational modifications, but matching and scoring peaks with unknown masses remains challenging. Here, the authors present a refined open search strategy to score all peaks with higher sensitivity and accuracy.
format	article
author	Fengchao Yu Guo Ci Teo Andy T. Kong Sarah E. Haynes Dmitry M. Avtonomov Daniel J. Geiszler Alexey I. Nesvizhskii
author_facet	Fengchao Yu Guo Ci Teo Andy T. Kong Sarah E. Haynes Dmitry M. Avtonomov Daniel J. Geiszler Alexey I. Nesvizhskii
author_sort	Fengchao Yu
title	Identification of modified peptides using localization-aware open search
title_short	Identification of modified peptides using localization-aware open search
title_full	Identification of modified peptides using localization-aware open search
title_fullStr	Identification of modified peptides using localization-aware open search
title_full_unstemmed	Identification of modified peptides using localization-aware open search
title_sort	identification of modified peptides using localization-aware open search
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02387a43c32348a9b61aa02e3a3e2a42
work_keys_str_mv	AT fengchaoyu identificationofmodifiedpeptidesusinglocalizationawareopensearch AT guociteo identificationofmodifiedpeptidesusinglocalizationawareopensearch AT andytkong identificationofmodifiedpeptidesusinglocalizationawareopensearch AT sarahehaynes identificationofmodifiedpeptidesusinglocalizationawareopensearch AT dmitrymavtonomov identificationofmodifiedpeptidesusinglocalizationawareopensearch AT danieljgeiszler identificationofmodifiedpeptidesusinglocalizationawareopensearch AT alexeyinesvizhskii identificationofmodifiedpeptidesusinglocalizationawareopensearch
_version_	1718377425104011264

Identification of modified peptides using localization-aware open search

Ejemplares similares