Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats

Abstract Olive leaves are rich in bioactive substances which exert anti-inflammatory, antioxidant, insulin-sensitizing and antihypertensive effects. The aim of this study was to analyze the possible beneficial effects of an olive leaf extract (OLE) rich in secoiridoids and phenolic compounds on the...

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Autores principales:	Daniel González-Hedström, Ángel Luís García-Villalón, Sara Amor, María de la Fuente-Fernández, Paula Almodóvar, Marin Prodanov, Teresa Priego, Ana Isabel Martín, Antonio Manuel Inarejos-García, Miriam Granado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0238f2d57784414da706929bbbfa6625
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spelling	oai:doaj.org-article:0238f2d57784414da706929bbbfa66252021-12-02T18:03:21ZOlive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats10.1038/s41598-021-87628-72045-2322https://doaj.org/article/0238f2d57784414da706929bbbfa66252021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87628-7https://doaj.org/toc/2045-2322Abstract Olive leaves are rich in bioactive substances which exert anti-inflammatory, antioxidant, insulin-sensitizing and antihypertensive effects. The aim of this study was to analyze the possible beneficial effects of an olive leaf extract (OLE) rich in secoiridoids and phenolic compounds on the aging-induced metabolic and vascular alterations. Three experimental groups of rats were used: 3-month-old rats, 24-month-old rats and 24-month-old rats supplemented 21 days with OLE (100 mg/kg). Administration of OLE to aged rats decreased the weight of adrenal glands and prevented the aging-induced loss of body weight and muscle mass. In the serum, OLE reduced the circulating levels of LDL-cholesterol and IL-6 and increased the concentrations of leptin and adiponectin. In the liver OLE attenuated the decreased gene expression of SOD-1, GSR, GCK and GSK-3β and reduced the aging-induced overexpression of NOX-4, Alox-5, iNOS and TNF-α. In aorta segments, OLE prevented endothelial dysfunction and vascular insulin resistance and improved vasoconstriction in response to KCl and NA. Improvement in vascular function was associated with the attenuation of the alterations in the gene expression of COX-2, IL-6, GPx, NOX-1 and IL-10. In conclusion, OLE exerts anti-inflammatory and antioxidant effects in aged rats and attenuates the alterations in vascular function associated with aging.Daniel González-HedströmÁngel Luís García-VillalónSara AmorMaría de la Fuente-FernándezPaula AlmodóvarMarin ProdanovTeresa PriegoAna Isabel MartínAntonio Manuel Inarejos-GarcíaMiriam GranadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel González-Hedström Ángel Luís García-Villalón Sara Amor María de la Fuente-Fernández Paula Almodóvar Marin Prodanov Teresa Priego Ana Isabel Martín Antonio Manuel Inarejos-García Miriam Granado Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
description	Abstract Olive leaves are rich in bioactive substances which exert anti-inflammatory, antioxidant, insulin-sensitizing and antihypertensive effects. The aim of this study was to analyze the possible beneficial effects of an olive leaf extract (OLE) rich in secoiridoids and phenolic compounds on the aging-induced metabolic and vascular alterations. Three experimental groups of rats were used: 3-month-old rats, 24-month-old rats and 24-month-old rats supplemented 21 days with OLE (100 mg/kg). Administration of OLE to aged rats decreased the weight of adrenal glands and prevented the aging-induced loss of body weight and muscle mass. In the serum, OLE reduced the circulating levels of LDL-cholesterol and IL-6 and increased the concentrations of leptin and adiponectin. In the liver OLE attenuated the decreased gene expression of SOD-1, GSR, GCK and GSK-3β and reduced the aging-induced overexpression of NOX-4, Alox-5, iNOS and TNF-α. In aorta segments, OLE prevented endothelial dysfunction and vascular insulin resistance and improved vasoconstriction in response to KCl and NA. Improvement in vascular function was associated with the attenuation of the alterations in the gene expression of COX-2, IL-6, GPx, NOX-1 and IL-10. In conclusion, OLE exerts anti-inflammatory and antioxidant effects in aged rats and attenuates the alterations in vascular function associated with aging.
format	article
author	Daniel González-Hedström Ángel Luís García-Villalón Sara Amor María de la Fuente-Fernández Paula Almodóvar Marin Prodanov Teresa Priego Ana Isabel Martín Antonio Manuel Inarejos-García Miriam Granado
author_facet	Daniel González-Hedström Ángel Luís García-Villalón Sara Amor María de la Fuente-Fernández Paula Almodóvar Marin Prodanov Teresa Priego Ana Isabel Martín Antonio Manuel Inarejos-García Miriam Granado
author_sort	Daniel González-Hedström
title	Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
title_short	Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
title_full	Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
title_fullStr	Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
title_full_unstemmed	Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
title_sort	olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in wistar rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0238f2d57784414da706929bbbfa6625
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Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats

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