The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

Lung cancer has the highest death rates. Aerosol drug delivery has been used for other lung diseases. The use of inhaled vanadium (V) as an option for lung cancer treatment is explored. Four groups of mice were studied: (1) Saline inhalation alone, (2) Single intraperitoneal (i.p.) dose of urethane,...

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Autores principales:	Nelly López-Valdez, Marcela Rojas-Lemus, Teresa I. Fortoul
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	urethane vanadium aerosol delivery lung cancer apoptosis antineoplastic Inorganic chemistry QD146-197
Acceso en línea:	https://doaj.org/article/023ba74deac1400fbaa9fa692ba87b26
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spelling	oai:doaj.org-article:023ba74deac1400fbaa9fa692ba87b262021-11-25T17:58:56ZThe Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model10.3390/inorganics91100782304-6740https://doaj.org/article/023ba74deac1400fbaa9fa692ba87b262021-10-01T00:00:00Zhttps://www.mdpi.com/2304-6740/9/11/78https://doaj.org/toc/2304-6740Lung cancer has the highest death rates. Aerosol drug delivery has been used for other lung diseases. The use of inhaled vanadium (V) as an option for lung cancer treatment is explored. Four groups of mice were studied: (1) Saline inhalation alone, (2) Single intraperitoneal (i.p.) dose of urethane, (3) V nebulization twice a week (Wk) for 8 Wk, and (4) A single dose of urethane and V nebulization for 8 Wk. Mice were sacrificed at the end of the experiment. Number and size of tumors, PCNA (proliferating cell nuclear antigen) and TUNEL (terminal deoxynucleotidyl tranferase dUTP nick-end labeling) immunohistochemistry were evaluated and compared within groups. Results: The size and number of tumors decreased in mice exposed to V-urethane and the TUNEL increased in this group; differences in the PCNA were not observed. Conclusions: Aerosol V delivery increased apoptosis and possibly the growth arrest of the tumors with no respiratory clinical changes in the mice.Nelly López-ValdezMarcela Rojas-LemusTeresa I. FortoulMDPI AGarticleurethanevanadiumaerosol deliverylung cancerapoptosisantineoplasticInorganic chemistryQD146-197ENInorganics, Vol 9, Iss 78, p 78 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urethane vanadium aerosol delivery lung cancer apoptosis antineoplastic Inorganic chemistry QD146-197
spellingShingle	urethane vanadium aerosol delivery lung cancer apoptosis antineoplastic Inorganic chemistry QD146-197 Nelly López-Valdez Marcela Rojas-Lemus Teresa I. Fortoul The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
description	Lung cancer has the highest death rates. Aerosol drug delivery has been used for other lung diseases. The use of inhaled vanadium (V) as an option for lung cancer treatment is explored. Four groups of mice were studied: (1) Saline inhalation alone, (2) Single intraperitoneal (i.p.) dose of urethane, (3) V nebulization twice a week (Wk) for 8 Wk, and (4) A single dose of urethane and V nebulization for 8 Wk. Mice were sacrificed at the end of the experiment. Number and size of tumors, PCNA (proliferating cell nuclear antigen) and TUNEL (terminal deoxynucleotidyl tranferase dUTP nick-end labeling) immunohistochemistry were evaluated and compared within groups. Results: The size and number of tumors decreased in mice exposed to V-urethane and the TUNEL increased in this group; differences in the PCNA were not observed. Conclusions: Aerosol V delivery increased apoptosis and possibly the growth arrest of the tumors with no respiratory clinical changes in the mice.
format	article
author	Nelly López-Valdez Marcela Rojas-Lemus Teresa I. Fortoul
author_facet	Nelly López-Valdez Marcela Rojas-Lemus Teresa I. Fortoul
author_sort	Nelly López-Valdez
title	The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
title_short	The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
title_full	The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
title_fullStr	The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
title_full_unstemmed	The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model
title_sort	effect of vanadium inhalation on the tumor progression of urethane-induced lung adenomas in a mice model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/023ba74deac1400fbaa9fa692ba87b26
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The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

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