HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release.

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Autores principales:	Joseph Kononchik, Joanna Ireland, Zhongcheng Zou, Jason Segura, Genevieve Holzapfel, Ashley Chastain, Ruipeng Wang, Matthew Spencer, Biao He, Nicole Stutzman, Daiji Kano, James Arthos, Elizabeth Fischer, Tae-Wook Chun, Susan Moir, Peter Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/023be22033d84ab98d9ba72dcb2e0344
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:023be22033d84ab98d9ba72dcb2e03442021-12-02T17:31:59ZHIV-1 targets L-selectin for adhesion and induces its shedding for viral release10.1038/s41467-018-05197-22041-1723https://doaj.org/article/023be22033d84ab98d9ba72dcb2e03442018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05197-2https://doaj.org/toc/2041-1723HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release.Joseph KononchikJoanna IrelandZhongcheng ZouJason SeguraGenevieve HolzapfelAshley ChastainRuipeng WangMatthew SpencerBiao HeNicole StutzmanDaiji KanoJames ArthosElizabeth FischerTae-Wook ChunSusan MoirPeter SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph Kononchik Joanna Ireland Zhongcheng Zou Jason Segura Genevieve Holzapfel Ashley Chastain Ruipeng Wang Matthew Spencer Biao He Nicole Stutzman Daiji Kano James Arthos Elizabeth Fischer Tae-Wook Chun Susan Moir Peter Sun HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
description	HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release.
format	article
author	Joseph Kononchik Joanna Ireland Zhongcheng Zou Jason Segura Genevieve Holzapfel Ashley Chastain Ruipeng Wang Matthew Spencer Biao He Nicole Stutzman Daiji Kano James Arthos Elizabeth Fischer Tae-Wook Chun Susan Moir Peter Sun
author_facet	Joseph Kononchik Joanna Ireland Zhongcheng Zou Jason Segura Genevieve Holzapfel Ashley Chastain Ruipeng Wang Matthew Spencer Biao He Nicole Stutzman Daiji Kano James Arthos Elizabeth Fischer Tae-Wook Chun Susan Moir Peter Sun
author_sort	Joseph Kononchik
title	HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
title_short	HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
title_full	HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
title_fullStr	HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
title_full_unstemmed	HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
title_sort	hiv-1 targets l-selectin for adhesion and induces its shedding for viral release
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/023be22033d84ab98d9ba72dcb2e0344
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HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

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