FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN

Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military...

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Autores principales:	Kamil Rehman Butt, Andaleeb Khan, Ali Muhammad, Jawad Khan, Ejaz Ali, Usama Bin Zubair
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	atorvastatin diabetes mellitus myopathy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/023cd1329ba348988832151cef0c5132
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spelling	oai:doaj.org-article:023cd1329ba348988832151cef0c51322021-12-02T17:10:36ZFREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN0030-96482411-884210.51253/pafmj.v71i2.2924https://doaj.org/article/023cd1329ba348988832151cef0c51322021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2924https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital Rawalpindi from, Jul to Dec 2018. Methodology: A total of 166 patients of both genders with type 2 diabetes mellitus taking atorvastatin for at least three to twelve months were included. Blood samples were drawn and Creatinine kinase (CK) levels were determined by automated analysis by colorimetry. Myopathy was taken as muscle symptoms associated with elevations in Creatinine Kinase at least 10 times the upper limit of normal. Results: Mean age of patients was 51.530 ± 5.70 years with age range from 40-70 years with. Mean duration of diabetes was 6.174 ± 2.27 years, mean duration of taking atorvastatin 7.186 ± 2.17 months and mean creatinine kinase levels were 1760.325 ± 5111.71 IU/L. Males were 68.7% as compare to females 31.3%. Myopathy was seen in 8.4% patients. Long duration of Diabetes Mellitus and atorvastatin use was statistically significantly related with the presence of myopathy. Conclusion: Myopathy was found in a significant number of patients taking atorvastatin. High risk population in our study emerged out to be patients with long duration of Diabetes Mellitus and long use of atorvastatin.Kamil Rehman ButtAndaleeb KhanAli MuhammadJawad KhanEjaz AliUsama Bin ZubairArmy Medical College Rawalpindiarticleatorvastatindiabetes mellitusmyopathyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 482-85 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atorvastatin diabetes mellitus myopathy Medicine R Medicine (General) R5-920
spellingShingle	atorvastatin diabetes mellitus myopathy Medicine R Medicine (General) R5-920 Kamil Rehman Butt Andaleeb Khan Ali Muhammad Jawad Khan Ejaz Ali Usama Bin Zubair FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
description	Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital Rawalpindi from, Jul to Dec 2018. Methodology: A total of 166 patients of both genders with type 2 diabetes mellitus taking atorvastatin for at least three to twelve months were included. Blood samples were drawn and Creatinine kinase (CK) levels were determined by automated analysis by colorimetry. Myopathy was taken as muscle symptoms associated with elevations in Creatinine Kinase at least 10 times the upper limit of normal. Results: Mean age of patients was 51.530 ± 5.70 years with age range from 40-70 years with. Mean duration of diabetes was 6.174 ± 2.27 years, mean duration of taking atorvastatin 7.186 ± 2.17 months and mean creatinine kinase levels were 1760.325 ± 5111.71 IU/L. Males were 68.7% as compare to females 31.3%. Myopathy was seen in 8.4% patients. Long duration of Diabetes Mellitus and atorvastatin use was statistically significantly related with the presence of myopathy. Conclusion: Myopathy was found in a significant number of patients taking atorvastatin. High risk population in our study emerged out to be patients with long duration of Diabetes Mellitus and long use of atorvastatin.
format	article
author	Kamil Rehman Butt Andaleeb Khan Ali Muhammad Jawad Khan Ejaz Ali Usama Bin Zubair
author_facet	Kamil Rehman Butt Andaleeb Khan Ali Muhammad Jawad Khan Ejaz Ali Usama Bin Zubair
author_sort	Kamil Rehman Butt
title	FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
title_short	FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
title_full	FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
title_fullStr	FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
title_full_unstemmed	FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN
title_sort	frequency and correlates of myopathy in patients with diabetes taking atorvastatin
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/023cd1329ba348988832151cef0c5132
work_keys_str_mv	AT kamilrehmanbutt frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin AT andaleebkhan frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin AT alimuhammad frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin AT jawadkhan frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin AT ejazali frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin AT usamabinzubair frequencyandcorrelatesofmyopathyinpatientswithdiabetestakingatorvastatin
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FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN

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