A cysteine selenosulfide redox switch for protein chemical synthesis

Control of cysteine reactivity is of paramount importance for the synthesis of proteins using native chemical ligation. Here, the authors report a readily cleavable N-selenoethyl group attached to cysteine and apply it to the modular assembly of linear and cyclic polypeptides.

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Autores principales:	Vincent Diemer, Nathalie Ollivier, Bérénice Leclercq, Hervé Drobecq, Jérôme Vicogne, Vangelis Agouridas, Oleg Melnyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/024061c5d12c406ea5bee1e0d5dcde35
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spelling	oai:doaj.org-article:024061c5d12c406ea5bee1e0d5dcde352021-12-02T14:58:51ZA cysteine selenosulfide redox switch for protein chemical synthesis10.1038/s41467-020-16359-62041-1723https://doaj.org/article/024061c5d12c406ea5bee1e0d5dcde352020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16359-6https://doaj.org/toc/2041-1723Control of cysteine reactivity is of paramount importance for the synthesis of proteins using native chemical ligation. Here, the authors report a readily cleavable N-selenoethyl group attached to cysteine and apply it to the modular assembly of linear and cyclic polypeptides.Vincent DiemerNathalie OllivierBérénice LeclercqHervé DrobecqJérôme VicogneVangelis AgouridasOleg MelnykNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent Diemer Nathalie Ollivier Bérénice Leclercq Hervé Drobecq Jérôme Vicogne Vangelis Agouridas Oleg Melnyk A cysteine selenosulfide redox switch for protein chemical synthesis
description	Control of cysteine reactivity is of paramount importance for the synthesis of proteins using native chemical ligation. Here, the authors report a readily cleavable N-selenoethyl group attached to cysteine and apply it to the modular assembly of linear and cyclic polypeptides.
format	article
author	Vincent Diemer Nathalie Ollivier Bérénice Leclercq Hervé Drobecq Jérôme Vicogne Vangelis Agouridas Oleg Melnyk
author_facet	Vincent Diemer Nathalie Ollivier Bérénice Leclercq Hervé Drobecq Jérôme Vicogne Vangelis Agouridas Oleg Melnyk
author_sort	Vincent Diemer
title	A cysteine selenosulfide redox switch for protein chemical synthesis
title_short	A cysteine selenosulfide redox switch for protein chemical synthesis
title_full	A cysteine selenosulfide redox switch for protein chemical synthesis
title_fullStr	A cysteine selenosulfide redox switch for protein chemical synthesis
title_full_unstemmed	A cysteine selenosulfide redox switch for protein chemical synthesis
title_sort	cysteine selenosulfide redox switch for protein chemical synthesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/024061c5d12c406ea5bee1e0d5dcde35
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A cysteine selenosulfide redox switch for protein chemical synthesis

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