Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children

Linda Litwin,1,2 Johnny KM Sundholm,1,3 Jelena Meinilä,4 Janne Kulmala,5 Tuija H Tammelin,5 Kristiina Rönö,6 Saila B Koivusalo,6 Johan G Eriksson,7– 10 Taisto Sarkola1,3 1Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 2Department of Congenital Heart...

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Autores principales:	Litwin L, Sundholm JKM, Meinilä J, Kulmala J, Tammelin TH, Rönö K, Koivusalo SB, Eriksson JG, Sarkola T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cardiovascular disease atherosclerosis carotid intima-media thickness risk factor child Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0242e33323ae4b7d82e23e972489949c
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id	oai:doaj.org-article:0242e33323ae4b7d82e23e972489949c
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease atherosclerosis carotid intima-media thickness risk factor child Specialties of internal medicine RC581-951
spellingShingle	cardiovascular disease atherosclerosis carotid intima-media thickness risk factor child Specialties of internal medicine RC581-951 Litwin L Sundholm JKM Meinilä J Kulmala J Tammelin TH Rönö K Koivusalo SB Eriksson JG Sarkola T Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
description	Linda Litwin,1,2 Johnny KM Sundholm,1,3 Jelena Meinilä,4 Janne Kulmala,5 Tuija H Tammelin,5 Kristiina Rönö,6 Saila B Koivusalo,6 Johan G Eriksson,7– 10 Taisto Sarkola1,3 1Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 2Department of Congenital Heart Defects and Pediatric Cardiology, FMS in Zabrze, Medical University of Silesia, Katowice, Poland; 3Minerva Foundation Institute for Medical Research, Helsinki, Finland; 4Department of Food and Nutrition, University of Helsinki, Helsinki, Finland; 5LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland; 6Women’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 7Folkhälsan Research Center, Helsinki, Finland; 8Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 9Human Potential Translational Research Programme and Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Singapore, Singapore; 10Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A&ast;STAR), SingaporeCorrespondence: Linda LitwinDepartment of Congenital Heart Defects and Pediatric Cardiology, FMS in Zabrze, Medical University of Silesia, M.Sklodowskiej-Curie 9, Zabrze, 41-800, PolandTel +48 322713401Fax +48 322713401Email linda.litwin@med.sum.edu.plBackground: Heredity and family-shared lifestyle contribute to cardiovascular risk, but the magnitude of their influence on arterial structure and function in early childhood is unknown. We aimed to assess associations between child and maternal ideal cardiovascular health, maternal subclinical atherosclerosis, and child arterial phenotype.Methods: Cross-sectional analysis of 201 mother-child pairs originating from the Finnish Gestational Diabetes Prevention Study (RADIEL) longitudinal cohort was done at child age 6.1 ± 0.5 years with assessments of ideal cardiovascular health (BMI, blood pressure, fasting glucose, total cholesterol, diet quality, physical activity, smoking), body composition, very-high frequency ultrasound of carotid arteries (25 and 35 MHz), and pulse wave velocity.Results: We found no association between child and maternal ideal cardiovascular health but report evidence of particular metrics correlations: total cholesterol (r=0.24, P=0.003), BMI (r=0.17, P=0.02), diastolic blood pressure (r=0.15, P=0.03), and diet quality (r=0.22, P=0.002). Child arterial phenotype was not associated with child or maternal ideal cardiovascular health. In the multivariable regression explanatory model adjusted for child sex, age, systolic blood pressure, lean body mass, and body fat percentage, child carotid intima-media thickness was independently associated only with maternal carotid intima-media thickness (0.1 mm increase [95% CI 0.05, 0.21, P=0.001] for each 1 mm increase in maternal carotid intima-media thickness). Children of mothers with subclinical atherosclerosis had decreased carotid artery distensibility (1.1 ± 0.2 vs 1.2 ± 0.2%/10 mmHg, P=0.01) and trend toward increased carotid intima-media thickness (0.37 ± 0.04 vs 0.35 ± 0.04 mm, P=0.06).Conclusion: Ideal Cardiovascular Health metrics are heterogeneously associated in mother-child pairs in early childhood. We found no evidence of child or maternal Ideal Cardiovascular Health effect on child arterial phenotype. Maternal carotid intima-media thickness predicts child carotid intima-media thickness, but the underlying mechanisms remain unclear. Maternal subclinical atherosclerosis is associated with local carotid arterial stiffness in early childhood.Keywords: cardiovascular disease, atherosclerosis, carotid intima-media thickness, risk factor, child
format	article
author	Litwin L Sundholm JKM Meinilä J Kulmala J Tammelin TH Rönö K Koivusalo SB Eriksson JG Sarkola T
author_facet	Litwin L Sundholm JKM Meinilä J Kulmala J Tammelin TH Rönö K Koivusalo SB Eriksson JG Sarkola T
author_sort	Litwin L
title	Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
title_short	Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
title_full	Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
title_fullStr	Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
title_full_unstemmed	Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children
title_sort	ideal cardiovascular health and vascular phenotype associations in mothers with obesity and their six-year-old children
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0242e33323ae4b7d82e23e972489949c
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spelling	oai:doaj.org-article:0242e33323ae4b7d82e23e972489949c2021-12-02T16:39:55ZIdeal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children1178-7007https://doaj.org/article/0242e33323ae4b7d82e23e972489949c2021-07-01T00:00:00Zhttps://www.dovepress.com/ideal-cardiovascular-health-and-vascular-phenotype-associations-in-mot-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Linda Litwin,1,2 Johnny KM Sundholm,1,3 Jelena Meinilä,4 Janne Kulmala,5 Tuija H Tammelin,5 Kristiina Rönö,6 Saila B Koivusalo,6 Johan G Eriksson,7– 10 Taisto Sarkola1,3 1Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 2Department of Congenital Heart Defects and Pediatric Cardiology, FMS in Zabrze, Medical University of Silesia, Katowice, Poland; 3Minerva Foundation Institute for Medical Research, Helsinki, Finland; 4Department of Food and Nutrition, University of Helsinki, Helsinki, Finland; 5LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland; 6Women’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 7Folkhälsan Research Center, Helsinki, Finland; 8Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 9Human Potential Translational Research Programme and Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Singapore, Singapore; 10Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A&ast;STAR), SingaporeCorrespondence: Linda LitwinDepartment of Congenital Heart Defects and Pediatric Cardiology, FMS in Zabrze, Medical University of Silesia, M.Sklodowskiej-Curie 9, Zabrze, 41-800, PolandTel +48 322713401Fax +48 322713401Email linda.litwin@med.sum.edu.plBackground: Heredity and family-shared lifestyle contribute to cardiovascular risk, but the magnitude of their influence on arterial structure and function in early childhood is unknown. We aimed to assess associations between child and maternal ideal cardiovascular health, maternal subclinical atherosclerosis, and child arterial phenotype.Methods: Cross-sectional analysis of 201 mother-child pairs originating from the Finnish Gestational Diabetes Prevention Study (RADIEL) longitudinal cohort was done at child age 6.1 ± 0.5 years with assessments of ideal cardiovascular health (BMI, blood pressure, fasting glucose, total cholesterol, diet quality, physical activity, smoking), body composition, very-high frequency ultrasound of carotid arteries (25 and 35 MHz), and pulse wave velocity.Results: We found no association between child and maternal ideal cardiovascular health but report evidence of particular metrics correlations: total cholesterol (r=0.24, P=0.003), BMI (r=0.17, P=0.02), diastolic blood pressure (r=0.15, P=0.03), and diet quality (r=0.22, P=0.002). Child arterial phenotype was not associated with child or maternal ideal cardiovascular health. In the multivariable regression explanatory model adjusted for child sex, age, systolic blood pressure, lean body mass, and body fat percentage, child carotid intima-media thickness was independently associated only with maternal carotid intima-media thickness (0.1 mm increase [95% CI 0.05, 0.21, P=0.001] for each 1 mm increase in maternal carotid intima-media thickness). Children of mothers with subclinical atherosclerosis had decreased carotid artery distensibility (1.1 ± 0.2 vs 1.2 ± 0.2%/10 mmHg, P=0.01) and trend toward increased carotid intima-media thickness (0.37 ± 0.04 vs 0.35 ± 0.04 mm, P=0.06).Conclusion: Ideal Cardiovascular Health metrics are heterogeneously associated in mother-child pairs in early childhood. We found no evidence of child or maternal Ideal Cardiovascular Health effect on child arterial phenotype. Maternal carotid intima-media thickness predicts child carotid intima-media thickness, but the underlying mechanisms remain unclear. Maternal subclinical atherosclerosis is associated with local carotid arterial stiffness in early childhood.Keywords: cardiovascular disease, atherosclerosis, carotid intima-media thickness, risk factor, childLitwin LSundholm JKMMeinilä JKulmala JTammelin THRönö KKoivusalo SBEriksson JGSarkola TDove Medical Pressarticlecardiovascular diseaseatherosclerosiscarotid intima-media thicknessrisk factorchildSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3187-3197 (2021)

Ideal Cardiovascular Health and Vascular Phenotype Associations in Mothers with Obesity and Their Six-Year-Old Children

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