Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing

Lu Wen,1 Pei Zeng,1 Liping Zhang,1 Wenli Huang,1 Hui Wang,2 Gang Chen1 1Department of Pharmaceutics, School of Pharmacy, 2School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: In this study, silver n...

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Autores principales:	Wen L, Zeng P, Zhang L, Huang W, Wang H, Chen G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Silver nanoparticles Orchidantha chinensis Endophytic fungi Symbiosis theory Wound healing. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0243532a7bf2425aa89a9aa1c11a25dd
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spelling	oai:doaj.org-article:0243532a7bf2425aa89a9aa1c11a25dd2021-12-02T01:01:58ZSymbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing1178-2013https://doaj.org/article/0243532a7bf2425aa89a9aa1c11a25dd2016-06-01T00:00:00Zhttps://www.dovepress.com/symbiosis-theory-directed-green-synthesis-of-silver-nanoparticles-and--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lu Wen,1 Pei Zeng,1 Liping Zhang,1 Wenli Huang,1 Hui Wang,2 Gang Chen1 1Department of Pharmaceutics, School of Pharmacy, 2School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: In this study, silver nanoparticles (AgNPs) were synthesized for the first time using an antibacterial endophytic fungus of Chinese medicinal herb Orchidantha chinensis, which has anti-inflammatory and antimicrobial activities. The AgNPs were analyzed by various characterization techniques to reveal their morphology, chemical composition, and stability. Also, the relationship between Chinese medicinal herbs, endophytic fungi, and the property of AgNPs was investigated for the first time. Interestingly, an experiment performed in this study revealed the proteins produced by the endophytic fungus to be capped on the nanoparticles, which led to an increase in the stability of spherical and polydispersed AgNPs with low aggregation for over 6 months. More importantly, further study demonstrated that the AgNPs possessed superior antibacterial activity and effectively promoted wound healing. Altogether, the biosynthesis of active AgNPs using the endophytic fungus from Chinese medicinal herb based on the symbiosis theory is simple, eco-friendly, and promising. Keywords: silver nanoparticles, Orchidantha chinensis, endophytic fungi, symbiosis theory, wound healingWen LZeng PZhang LHuang WWang HChen GDove Medical PressarticleSilver nanoparticlesOrchidantha chinensisEndophytic fungiSymbiosis theoryWound healing.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2757-2767 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silver nanoparticles Orchidantha chinensis Endophytic fungi Symbiosis theory Wound healing. Medicine (General) R5-920
spellingShingle	Silver nanoparticles Orchidantha chinensis Endophytic fungi Symbiosis theory Wound healing. Medicine (General) R5-920 Wen L Zeng P Zhang L Huang W Wang H Chen G Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
description	Lu Wen,1 Pei Zeng,1 Liping Zhang,1 Wenli Huang,1 Hui Wang,2 Gang Chen1 1Department of Pharmaceutics, School of Pharmacy, 2School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: In this study, silver nanoparticles (AgNPs) were synthesized for the first time using an antibacterial endophytic fungus of Chinese medicinal herb Orchidantha chinensis, which has anti-inflammatory and antimicrobial activities. The AgNPs were analyzed by various characterization techniques to reveal their morphology, chemical composition, and stability. Also, the relationship between Chinese medicinal herbs, endophytic fungi, and the property of AgNPs was investigated for the first time. Interestingly, an experiment performed in this study revealed the proteins produced by the endophytic fungus to be capped on the nanoparticles, which led to an increase in the stability of spherical and polydispersed AgNPs with low aggregation for over 6 months. More importantly, further study demonstrated that the AgNPs possessed superior antibacterial activity and effectively promoted wound healing. Altogether, the biosynthesis of active AgNPs using the endophytic fungus from Chinese medicinal herb based on the symbiosis theory is simple, eco-friendly, and promising. Keywords: silver nanoparticles, Orchidantha chinensis, endophytic fungi, symbiosis theory, wound healing
format	article
author	Wen L Zeng P Zhang L Huang W Wang H Chen G
author_facet	Wen L Zeng P Zhang L Huang W Wang H Chen G
author_sort	Wen L
title	Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
title_short	Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
title_full	Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
title_fullStr	Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
title_full_unstemmed	Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
title_sort	symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0243532a7bf2425aa89a9aa1c11a25dd
work_keys_str_mv	AT wenl symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing AT zengp symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing AT zhangl symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing AT huangw symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing AT wangh symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing AT cheng symbiosistheorydirectedgreensynthesisofsilvernanoparticlesandtheirapplicationininfectedwoundhealing
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Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing

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