Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure

The real-world evidence has been sparse on the impact of non-invasive positive pressure ventilation (NPPV) on the outcomes in acute decompensated heart failure (ADHF) patients. We aim to explore this issue in the prospective multicenter WET-HF registry. Among 3927 patients (77 (67–84) years, male 60...

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Autores principales:	Midori Yukino, Yuji Nagatomo, Ayumi Goda, Takashi Kohno, Makoto Takei, Yosuke Nishihata, Mike Saji, Yuichi Toyosaki, Shintaro Nakano, Yukinori Ikegami, Yasuyuki Shiraishi, Shun Kohsaka, Takeshi Adachi, Tsutomu Yoshikawa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NPPV acute decompensated heart failure ischemic heart disease intensive care endotracheal intubation length of hospital stay Medicine R
Acceso en línea:	https://doaj.org/article/0243f1c6f094429db04bc35ab4241b7b
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spelling	oai:doaj.org-article:0243f1c6f094429db04bc35ab4241b7b2021-11-11T17:42:41ZAssociation of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure10.3390/jcm102150922077-0383https://doaj.org/article/0243f1c6f094429db04bc35ab4241b7b2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5092https://doaj.org/toc/2077-0383The real-world evidence has been sparse on the impact of non-invasive positive pressure ventilation (NPPV) on the outcomes in acute decompensated heart failure (ADHF) patients. We aim to explore this issue in the prospective multicenter WET-HF registry. Among 3927 patients (77 (67–84) years, male 60%), the NPPV was used in 775 patients (19.7%). The association of NPPV use with in-hospital outcome and length of hospital stay (LOS) was examined by two methods, propensity score (PS) matching and multivariable analysis with adjustment for PS. In these analyses the NPPV group exhibited a lower endotracheal intubation (ETI) rate and a comparable in-hospital mortality, but longer LOS compared to the non-NPPV group. In the stratified analysis, the NPPV group exhibited a significantly lower ETI rate in patients with ischemic etiology, systolic blood pressure (sBP) > 140 mmHg and the Controlling Nutritional Status (CONUT) score ≤ 3, indicating better nutritional status. On the contrary, NPPV use was associated with longer LOS in patients with non-ischemic etiology, sBP < 100 mmHg and CONUT score > 3. In conclusion, NPPV use was associated with a lower incidence of ETI. Particularly, patients with ischemic etiology, high sBP, and better nutritional status might benefit from NPPV use.Midori YukinoYuji NagatomoAyumi GodaTakashi KohnoMakoto TakeiYosuke NishihataMike SajiYuichi ToyosakiShintaro NakanoYukinori IkegamiYasuyuki ShiraishiShun KohsakaTakeshi AdachiTsutomu YoshikawaMDPI AGarticleNPPVacute decompensated heart failureischemic heart diseaseintensive careendotracheal intubationlength of hospital stayMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5092, p 5092 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NPPV acute decompensated heart failure ischemic heart disease intensive care endotracheal intubation length of hospital stay Medicine R
spellingShingle	NPPV acute decompensated heart failure ischemic heart disease intensive care endotracheal intubation length of hospital stay Medicine R Midori Yukino Yuji Nagatomo Ayumi Goda Takashi Kohno Makoto Takei Yosuke Nishihata Mike Saji Yuichi Toyosaki Shintaro Nakano Yukinori Ikegami Yasuyuki Shiraishi Shun Kohsaka Takeshi Adachi Tsutomu Yoshikawa Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
description	The real-world evidence has been sparse on the impact of non-invasive positive pressure ventilation (NPPV) on the outcomes in acute decompensated heart failure (ADHF) patients. We aim to explore this issue in the prospective multicenter WET-HF registry. Among 3927 patients (77 (67–84) years, male 60%), the NPPV was used in 775 patients (19.7%). The association of NPPV use with in-hospital outcome and length of hospital stay (LOS) was examined by two methods, propensity score (PS) matching and multivariable analysis with adjustment for PS. In these analyses the NPPV group exhibited a lower endotracheal intubation (ETI) rate and a comparable in-hospital mortality, but longer LOS compared to the non-NPPV group. In the stratified analysis, the NPPV group exhibited a significantly lower ETI rate in patients with ischemic etiology, systolic blood pressure (sBP) > 140 mmHg and the Controlling Nutritional Status (CONUT) score ≤ 3, indicating better nutritional status. On the contrary, NPPV use was associated with longer LOS in patients with non-ischemic etiology, sBP < 100 mmHg and CONUT score > 3. In conclusion, NPPV use was associated with a lower incidence of ETI. Particularly, patients with ischemic etiology, high sBP, and better nutritional status might benefit from NPPV use.
format	article
author	Midori Yukino Yuji Nagatomo Ayumi Goda Takashi Kohno Makoto Takei Yosuke Nishihata Mike Saji Yuichi Toyosaki Shintaro Nakano Yukinori Ikegami Yasuyuki Shiraishi Shun Kohsaka Takeshi Adachi Tsutomu Yoshikawa
author_facet	Midori Yukino Yuji Nagatomo Ayumi Goda Takashi Kohno Makoto Takei Yosuke Nishihata Mike Saji Yuichi Toyosaki Shintaro Nakano Yukinori Ikegami Yasuyuki Shiraishi Shun Kohsaka Takeshi Adachi Tsutomu Yoshikawa
author_sort	Midori Yukino
title	Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
title_short	Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
title_full	Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
title_fullStr	Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
title_full_unstemmed	Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure
title_sort	association of non-invasive positive pressure ventilation with short-term clinical outcomes in patients hospitalized for acute decompensated heart failure
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0243f1c6f094429db04bc35ab4241b7b
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Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure

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