Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here the authors use ~40 nm cationic nanoparticles to scavenge cfDNA, and demonstrate the potential for nanomedicine to relieve debilitating RA symptoms....

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Autores principales:	Huiyi Liang, Bo Peng, Cong Dong, Lixin Liu, Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen, Hai-Quan Mao, Xiaohu Gao, Kam W. Leong, Yongming Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0244d19b30be45d699b6a429c7e120e0
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spelling	oai:doaj.org-article:0244d19b30be45d699b6a429c7e120e02021-12-02T15:33:35ZCationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation10.1038/s41467-018-06603-52041-1723https://doaj.org/article/0244d19b30be45d699b6a429c7e120e02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06603-5https://doaj.org/toc/2041-1723Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here the authors use ~40 nm cationic nanoparticles to scavenge cfDNA, and demonstrate the potential for nanomedicine to relieve debilitating RA symptoms.Huiyi LiangBo PengCong DongLixin LiuJiaji MaoSong WeiXinlu WangHanshi XuJun ShenHai-Quan MaoXiaohu GaoKam W. LeongYongming ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huiyi Liang Bo Peng Cong Dong Lixin Liu Jiaji Mao Song Wei Xinlu Wang Hanshi Xu Jun Shen Hai-Quan Mao Xiaohu Gao Kam W. Leong Yongming Chen Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
description	Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here the authors use ~40 nm cationic nanoparticles to scavenge cfDNA, and demonstrate the potential for nanomedicine to relieve debilitating RA symptoms.
format	article
author	Huiyi Liang Bo Peng Cong Dong Lixin Liu Jiaji Mao Song Wei Xinlu Wang Hanshi Xu Jun Shen Hai-Quan Mao Xiaohu Gao Kam W. Leong Yongming Chen
author_facet	Huiyi Liang Bo Peng Cong Dong Lixin Liu Jiaji Mao Song Wei Xinlu Wang Hanshi Xu Jun Shen Hai-Quan Mao Xiaohu Gao Kam W. Leong Yongming Chen
author_sort	Huiyi Liang
title	Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
title_short	Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
title_full	Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
title_fullStr	Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
title_full_unstemmed	Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
title_sort	cationic nanoparticle as an inhibitor of cell-free dna-induced inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0244d19b30be45d699b6a429c7e120e0
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Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

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