α-cell glucokinase suppresses glucose-regulated glucagon secretion

α-cell glucokinase suppresses glucose-regulated glucagon secretion

Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of KATP channels in α-cells.

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Autores principales: Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/0248c76c4524407a805ca6e24356aff3
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spelling oai:doaj.org-article:0248c76c4524407a805ca6e24356aff32021-12-02T17:31:15Zα-cell glucokinase suppresses glucose-regulated glucagon secretion10.1038/s41467-018-03034-02041-1723https://doaj.org/article/0248c76c4524407a805ca6e24356aff32018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03034-0https://doaj.org/toc/2041-1723Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of KATP channels in α-cells.Davide BascoQuan ZhangAlbert SalehiAndrei TarasovWanda DolciPedro HerreraIoannis SpiliotisXavier BerneyDavid TarussioPatrik RorsmanBernard ThorensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Davide Basco
Quan Zhang
Albert Salehi
Andrei Tarasov
Wanda Dolci
Pedro Herrera
Ioannis Spiliotis
Xavier Berney
David Tarussio
Patrik Rorsman
Bernard Thorens
α-cell glucokinase suppresses glucose-regulated glucagon secretion
description Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of KATP channels in α-cells.
format article
author Davide Basco
Quan Zhang
Albert Salehi
Andrei Tarasov
Wanda Dolci
Pedro Herrera
Ioannis Spiliotis
Xavier Berney
David Tarussio
Patrik Rorsman
Bernard Thorens
author_facet Davide Basco
Quan Zhang
Albert Salehi
Andrei Tarasov
Wanda Dolci
Pedro Herrera
Ioannis Spiliotis
Xavier Berney
David Tarussio
Patrik Rorsman
Bernard Thorens
author_sort Davide Basco
title α-cell glucokinase suppresses glucose-regulated glucagon secretion
title_short α-cell glucokinase suppresses glucose-regulated glucagon secretion
title_full α-cell glucokinase suppresses glucose-regulated glucagon secretion
title_fullStr α-cell glucokinase suppresses glucose-regulated glucagon secretion
title_full_unstemmed α-cell glucokinase suppresses glucose-regulated glucagon secretion
title_sort α-cell glucokinase suppresses glucose-regulated glucagon secretion
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0248c76c4524407a805ca6e24356aff3
work_keys_str_mv AT davidebasco acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT quanzhang acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT albertsalehi acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT andreitarasov acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT wandadolci acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT pedroherrera acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT ioannisspiliotis acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT xavierberney acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT davidtarussio acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT patrikrorsman acellglucokinasesuppressesglucoseregulatedglucagonsecretion
AT bernardthorens acellglucokinasesuppressesglucoseregulatedglucagonsecretion
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