Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects

Allancer DC Nunes,1 Laylla S Ramalho,2 Álvaro PS Souza,1 Elizabeth P Mendes,1,3 Diego B Colugnati,1 Nícholas Zufelato,2 Marcelo H Sousa,4 Andris F Bakuzis,2 Carlos H Castro1,3 1Department of Physiological ...

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Autores principales:	Nunes ADC, Ramalho LS, Souza APS, Mendes EP, Colugnati DB, Zufelato N, Sousa MH, Bakuzis AF, Castro CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/02495c491bb5493cbad6eb7df607a051
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spelling	oai:doaj.org-article:02495c491bb5493cbad6eb7df607a0512021-12-02T01:34:04ZManganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects1178-2013https://doaj.org/article/02495c491bb5493cbad6eb7df607a0512014-07-01T00:00:00Zhttp://www.dovepress.com/manganese-ferrite-based-nanoparticles-induce-ex-vivo-but-not-in-vivo-c-a17522https://doaj.org/toc/1178-2013 Allancer DC Nunes,1 Laylla S Ramalho,2 Álvaro PS Souza,1 Elizabeth P Mendes,1,3 Diego B Colugnati,1 Nícholas Zufelato,2 Marcelo H Sousa,4 Andris F Bakuzis,2 Carlos H Castro1,3 1Department of Physiological Sciences, 2Physics Institute, Federal University of Goiás, Goiânia, Brazil; 3National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil; 4Faculty of Ceilândia, University of Brasília, Brasília-DF, Brazil Abstract: Magnetic nanoparticles (MNPs) have been used for various biomedical applications. Importantly, manganese ferrite-based nanoparticles have useful magnetic resonance imaging characteristics and potential for hyperthermia treatment, but their effects in the cardiovascular system are poorly reported. Thus, the objectives of this study were to determine the cardiovascular effects of three different types of manganese ferrite-based magnetic nanoparticles: citrate-coated (CiMNPs); tripolyphosphate-coated (PhMNPs); and bare magnetic nanoparticles (BaMNPs). The samples were characterized by vibrating sample magnetometer, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. The direct effects of the MNPs on cardiac contractility were evaluated in isolated perfused rat hearts. The CiMNPs, but not PhMNPs and BaMNPs, induced a transient decrease in the left ventricular end-systolic pressure. The PhMNPs and BaMNPs, but not CiMNPs, induced an increase in left ventricular end-diastolic pressure, which resulted in a decrease in a left ventricular end developed pressure. Indeed, PhMNPs and BaMNPs also caused a decrease in the maximal rate of left ventricular pressure rise (+dP/dt) and maximal rate of left ventricular pressure decline (–dP/dt). The three MNPs studied induced an increase in the perfusion pressure of isolated hearts. BaMNPs, but not PhMNPs or CiMNPs, induced a slight vasorelaxant effect in the isolated aortic rings. None of the MNPs were able to change heart rate or arterial blood pressure in conscious rats. In summary, although the MNPs were able to induce effects ex vivo, no significant changes were observed in vivo. Thus, given the proper dosages, these MNPs should be considered for possible therapeutic applications. Keywords: cardiac function, isolated heart, magnetic fluids, magnetic nanoparticles, nanomedicineNunes ADCRamalho LSSouza APSMendes EPColugnati DBZufelato NSousa MHBakuzis AFCastro CHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3299-3312 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nunes ADC Ramalho LS Souza APS Mendes EP Colugnati DB Zufelato N Sousa MH Bakuzis AF Castro CH Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
description	Allancer DC Nunes,1 Laylla S Ramalho,2 Álvaro PS Souza,1 Elizabeth P Mendes,1,3 Diego B Colugnati,1 Nícholas Zufelato,2 Marcelo H Sousa,4 Andris F Bakuzis,2 Carlos H Castro1,3 1Department of Physiological Sciences, 2Physics Institute, Federal University of Goiás, Goiânia, Brazil; 3National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil; 4Faculty of Ceilândia, University of Brasília, Brasília-DF, Brazil Abstract: Magnetic nanoparticles (MNPs) have been used for various biomedical applications. Importantly, manganese ferrite-based nanoparticles have useful magnetic resonance imaging characteristics and potential for hyperthermia treatment, but their effects in the cardiovascular system are poorly reported. Thus, the objectives of this study were to determine the cardiovascular effects of three different types of manganese ferrite-based magnetic nanoparticles: citrate-coated (CiMNPs); tripolyphosphate-coated (PhMNPs); and bare magnetic nanoparticles (BaMNPs). The samples were characterized by vibrating sample magnetometer, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. The direct effects of the MNPs on cardiac contractility were evaluated in isolated perfused rat hearts. The CiMNPs, but not PhMNPs and BaMNPs, induced a transient decrease in the left ventricular end-systolic pressure. The PhMNPs and BaMNPs, but not CiMNPs, induced an increase in left ventricular end-diastolic pressure, which resulted in a decrease in a left ventricular end developed pressure. Indeed, PhMNPs and BaMNPs also caused a decrease in the maximal rate of left ventricular pressure rise (+dP/dt) and maximal rate of left ventricular pressure decline (–dP/dt). The three MNPs studied induced an increase in the perfusion pressure of isolated hearts. BaMNPs, but not PhMNPs or CiMNPs, induced a slight vasorelaxant effect in the isolated aortic rings. None of the MNPs were able to change heart rate or arterial blood pressure in conscious rats. In summary, although the MNPs were able to induce effects ex vivo, no significant changes were observed in vivo. Thus, given the proper dosages, these MNPs should be considered for possible therapeutic applications. Keywords: cardiac function, isolated heart, magnetic fluids, magnetic nanoparticles, nanomedicine
format	article
author	Nunes ADC Ramalho LS Souza APS Mendes EP Colugnati DB Zufelato N Sousa MH Bakuzis AF Castro CH
author_facet	Nunes ADC Ramalho LS Souza APS Mendes EP Colugnati DB Zufelato N Sousa MH Bakuzis AF Castro CH
author_sort	Nunes ADC
title	Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
title_short	Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
title_full	Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
title_fullStr	Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
title_full_unstemmed	Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
title_sort	manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/02495c491bb5493cbad6eb7df607a051
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Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects

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