Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women

Abstract We have previously shown increased depression and anxiety scores in postmenopausal overweight women, when compared to overweight premenopausal women. The mechanisms responsible for these alterations are not understood. Although ghrelin involvement in mood modulation has been suggested, its...

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Autores principales:	Maria Fernanda Naufel, Amanda Paula Pedroso, Lila Missae Oyama, Mônica Marques Telles, Helena Hachul, Eliane Beraldi Ribeiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/024bb1b2d6d9486b933e25370c85b9c9
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spelling	oai:doaj.org-article:024bb1b2d6d9486b933e25370c85b9c92021-12-02T11:35:52ZPreliminary evidence of acylated ghrelin association with depression severity in postmenopausal women10.1038/s41598-021-84431-22045-2322https://doaj.org/article/024bb1b2d6d9486b933e25370c85b9c92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84431-2https://doaj.org/toc/2045-2322Abstract We have previously shown increased depression and anxiety scores in postmenopausal overweight women, when compared to overweight premenopausal women. The mechanisms responsible for these alterations are not understood. Although ghrelin involvement in mood modulation has been suggested, its role is still ambiguous and has not been evaluated in postmenopause. Here we investigated the association of ghrelin with depression and anxiety symptoms in postmenopausal women. Fifty-five postmenopausal women with depression symptoms, who were not in use of hormones or antidepressants, were included in the study. Depression symptoms were evaluated by Beck’s Depression Inventory (BDI) and Patient Health Questionnaire-9 (PHQ-9) and anxiety symptoms were evaluated by Beck’s Anxiety Inventory (BAI). Women were allocated into three groups, according to BDI classification of mild, moderate, or severe depression symptoms. Anthropometric, biochemical and hormonal parameters were analyzed. Total and acylated ghrelin levels were higher in the severe depression than in the mild depression group. Multivariate regression analyses showed positive associations of BDI scores with acylated ghrelin and BMI, and of PHQ-9 scores with acylated ghrelin and homeostasis model assessment of insulin resistance (HOMA-IR). BAI scores associated positively with waist-to-hip ratio. To the best of our knowledge, this is the first demonstration of an association between acylated ghrelin and the severity of depression symptoms in postmenopausal women. This association may reflect either a physiological response aimed at fighting against depression symptoms or a causal factor of this mental disorder.Maria Fernanda NaufelAmanda Paula PedrosoLila Missae OyamaMônica Marques TellesHelena HachulEliane Beraldi RibeiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Fernanda Naufel Amanda Paula Pedroso Lila Missae Oyama Mônica Marques Telles Helena Hachul Eliane Beraldi Ribeiro Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
description	Abstract We have previously shown increased depression and anxiety scores in postmenopausal overweight women, when compared to overweight premenopausal women. The mechanisms responsible for these alterations are not understood. Although ghrelin involvement in mood modulation has been suggested, its role is still ambiguous and has not been evaluated in postmenopause. Here we investigated the association of ghrelin with depression and anxiety symptoms in postmenopausal women. Fifty-five postmenopausal women with depression symptoms, who were not in use of hormones or antidepressants, were included in the study. Depression symptoms were evaluated by Beck’s Depression Inventory (BDI) and Patient Health Questionnaire-9 (PHQ-9) and anxiety symptoms were evaluated by Beck’s Anxiety Inventory (BAI). Women were allocated into three groups, according to BDI classification of mild, moderate, or severe depression symptoms. Anthropometric, biochemical and hormonal parameters were analyzed. Total and acylated ghrelin levels were higher in the severe depression than in the mild depression group. Multivariate regression analyses showed positive associations of BDI scores with acylated ghrelin and BMI, and of PHQ-9 scores with acylated ghrelin and homeostasis model assessment of insulin resistance (HOMA-IR). BAI scores associated positively with waist-to-hip ratio. To the best of our knowledge, this is the first demonstration of an association between acylated ghrelin and the severity of depression symptoms in postmenopausal women. This association may reflect either a physiological response aimed at fighting against depression symptoms or a causal factor of this mental disorder.
format	article
author	Maria Fernanda Naufel Amanda Paula Pedroso Lila Missae Oyama Mônica Marques Telles Helena Hachul Eliane Beraldi Ribeiro
author_facet	Maria Fernanda Naufel Amanda Paula Pedroso Lila Missae Oyama Mônica Marques Telles Helena Hachul Eliane Beraldi Ribeiro
author_sort	Maria Fernanda Naufel
title	Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
title_short	Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
title_full	Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
title_fullStr	Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
title_full_unstemmed	Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
title_sort	preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/024bb1b2d6d9486b933e25370c85b9c9
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Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women

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