Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.

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Detalles Bibliográficos
Autores principales: Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/024c2a17f581441ca1d27fe75c08a597
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Descripción
Sumario:The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.

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