Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.
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Nature Portfolio
2019
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oai:doaj.org-article:024c2a17f581441ca1d27fe75c08a5972021-12-02T16:57:21ZLysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter10.1038/s41467-019-10352-42041-1723https://doaj.org/article/024c2a17f581441ca1d27fe75c08a5972019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10352-4https://doaj.org/toc/2041-1723The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.Yueming ZhuXianghui ZouAngela E. DeanJoseph O’ BrienYucheng GaoElizabeth L. TranSeong-Hoon ParkGuoxiang LiuMatthew B. KiefferHaiyan JiangMelissa E. StaufferRobert HartSonghua QuanKarla J. F. SatchellNobuo HorikoshiMarcelo BoniniDavid GiusNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| description |
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor. |
| format |
article |
| author |
Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius |
| author_facet |
Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius |
| author_sort |
Yueming Zhu |
| title |
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_short |
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_full |
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_fullStr |
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_full_unstemmed |
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_sort |
lysine 68 acetylation directs mnsod as a tetrameric detoxification complex versus a monomeric tumor promoter |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/024c2a17f581441ca1d27fe75c08a597 |
| work_keys_str_mv |
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