CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs

To regulate its complex splicing pattern, HIV-1 uses the adaptor protein Rev to shuttle unspliced or partially spliced mRNA from the nucleus to the cytoplasm. In the absence of Rev, these RNAs are retained in the nucleus, but it is unclear why.

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Autores principales:	Han Xiao, Emanuel Wyler, Miha Milek, Bastian Grewe, Philipp Kirchner, Arif Ekici, Ana Beatriz Oliveira Villela Silva, Doris Jungnickl, Florian Full, Marco Thomas, Markus Landthaler, Armin Ensser, Klaus Überla
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/024fe1f1a6964e11a3329f44d73767b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:024fe1f1a6964e11a3329f44d73767b62021-11-03T18:15:38ZCRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs2161-21292150-751110.1128/mBio.02525-20https://doaj.org/article/024fe1f1a6964e11a3329f44d73767b62021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02525-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 To regulate its complex splicing pattern, HIV-1 uses the adaptor protein Rev to shuttle unspliced or partially spliced mRNA from the nucleus to the cytoplasm. In the absence of Rev, these RNAs are retained in the nucleus, but it is unclear why.Han XiaoEmanuel WylerMiha MilekBastian GrewePhilipp KirchnerArif EkiciAna Beatriz Oliveira Villela SilvaDoris JungnicklFlorian FullMarco ThomasMarkus LandthalerArmin EnsserKlaus ÜberlaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Han Xiao Emanuel Wyler Miha Milek Bastian Grewe Philipp Kirchner Arif Ekici Ana Beatriz Oliveira Villela Silva Doris Jungnickl Florian Full Marco Thomas Markus Landthaler Armin Ensser Klaus Überla CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
description	To regulate its complex splicing pattern, HIV-1 uses the adaptor protein Rev to shuttle unspliced or partially spliced mRNA from the nucleus to the cytoplasm. In the absence of Rev, these RNAs are retained in the nucleus, but it is unclear why.
format	article
author	Han Xiao Emanuel Wyler Miha Milek Bastian Grewe Philipp Kirchner Arif Ekici Ana Beatriz Oliveira Villela Silva Doris Jungnickl Florian Full Marco Thomas Markus Landthaler Armin Ensser Klaus Überla
author_facet	Han Xiao Emanuel Wyler Miha Milek Bastian Grewe Philipp Kirchner Arif Ekici Ana Beatriz Oliveira Villela Silva Doris Jungnickl Florian Full Marco Thomas Markus Landthaler Armin Ensser Klaus Überla
author_sort	Han Xiao
title	CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
title_short	CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
title_full	CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
title_fullStr	CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
title_full_unstemmed	CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
title_sort	crnkl1 is a highly selective regulator of intron-retaining hiv-1 and cellular mrnas
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/024fe1f1a6964e11a3329f44d73767b6
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CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs

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