Modeling HIV-1 drug resistance as episodic directional selection.

The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ben Murrell, Tulio de Oliveira, Chris Seebregts, Sergei L Kosakovsky Pond, Konrad Scheffler, Southern African Treatment and Resistance Network-SATuRN Consortium
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Acceso en línea:https://doaj.org/article/0250d2a864864594b00a00d55834bfdb
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!