Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.

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Autores principales:	Jian Fang, Jingdong Cheng, Jiaolong Wang, Qiao Zhang, Mengjie Liu, Rui Gong, Ping Wang, Xiaodan Zhang, Yangyang Feng, Wenxian Lan, Zhou Gong, Chun Tang, Jiemin Wong, Huirong Yang, Chunyang Cao, Yanhui Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02521234d2bf4d41aecfd4a08032380d
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spelling	oai:doaj.org-article:02521234d2bf4d41aecfd4a08032380d2021-12-02T15:35:20ZHemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition10.1038/ncomms111972041-1723https://doaj.org/article/02521234d2bf4d41aecfd4a08032380d2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11197https://doaj.org/toc/2041-1723UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.Jian FangJingdong ChengJiaolong WangQiao ZhangMengjie LiuRui GongPing WangXiaodan ZhangYangyang FengWenxian LanZhou GongChun TangJiemin WongHuirong YangChunyang CaoYanhui XuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Fang Jingdong Cheng Jiaolong Wang Qiao Zhang Mengjie Liu Rui Gong Ping Wang Xiaodan Zhang Yangyang Feng Wenxian Lan Zhou Gong Chun Tang Jiemin Wong Huirong Yang Chunyang Cao Yanhui Xu Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
description	UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.
format	article
author	Jian Fang Jingdong Cheng Jiaolong Wang Qiao Zhang Mengjie Liu Rui Gong Ping Wang Xiaodan Zhang Yangyang Feng Wenxian Lan Zhou Gong Chun Tang Jiemin Wong Huirong Yang Chunyang Cao Yanhui Xu
author_facet	Jian Fang Jingdong Cheng Jiaolong Wang Qiao Zhang Mengjie Liu Rui Gong Ping Wang Xiaodan Zhang Yangyang Feng Wenxian Lan Zhou Gong Chun Tang Jiemin Wong Huirong Yang Chunyang Cao Yanhui Xu
author_sort	Jian Fang
title	Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
title_short	Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
title_full	Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
title_fullStr	Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
title_full_unstemmed	Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
title_sort	hemi-methylated dna opens a closed conformation of uhrf1 to facilitate its histone recognition
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/02521234d2bf4d41aecfd4a08032380d
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Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

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