Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.

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Autores principales: Jian Fang, Jingdong Cheng, Jiaolong Wang, Qiao Zhang, Mengjie Liu, Rui Gong, Ping Wang, Xiaodan Zhang, Yangyang Feng, Wenxian Lan, Zhou Gong, Chun Tang, Jiemin Wong, Huirong Yang, Chunyang Cao, Yanhui Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/02521234d2bf4d41aecfd4a08032380d
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