Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows th...

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Autores principales:	Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0252ed6647884c3d9a7e3a856e52ca42
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spelling	oai:doaj.org-article:0252ed6647884c3d9a7e3a856e52ca422021-12-02T17:32:15ZInterplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy10.1038/s41467-018-07411-72041-1723https://doaj.org/article/0252ed6647884c3d9a7e3a856e52ca422018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07411-7https://doaj.org/toc/2041-1723Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalutamide.Hao GengChanghui XueJanet MendoncaXiao-Xin SunQiong LiuPatrick N. ReardonYingxiao ChenKendrick QianVivian HuaAlice ChenFreddy PanJulia YuanSang DangTomasz M. BeerMu-Shui DaiSushant K. KachhapDavid Z. QianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Geng Changhui Xue Janet Mendonca Xiao-Xin Sun Qiong Liu Patrick N. Reardon Yingxiao Chen Kendrick Qian Vivian Hua Alice Chen Freddy Pan Julia Yuan Sang Dang Tomasz M. Beer Mu-Shui Dai Sushant K. Kachhap David Z. Qian Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
description	Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalutamide.
format	article
author	Hao Geng Changhui Xue Janet Mendonca Xiao-Xin Sun Qiong Liu Patrick N. Reardon Yingxiao Chen Kendrick Qian Vivian Hua Alice Chen Freddy Pan Julia Yuan Sang Dang Tomasz M. Beer Mu-Shui Dai Sushant K. Kachhap David Z. Qian
author_facet	Hao Geng Changhui Xue Janet Mendonca Xiao-Xin Sun Qiong Liu Patrick N. Reardon Yingxiao Chen Kendrick Qian Vivian Hua Alice Chen Freddy Pan Julia Yuan Sang Dang Tomasz M. Beer Mu-Shui Dai Sushant K. Kachhap David Z. Qian
author_sort	Hao Geng
title	Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
title_short	Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
title_full	Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
title_fullStr	Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
title_full_unstemmed	Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
title_sort	interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/ar-targeted therapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0252ed6647884c3d9a7e3a856e52ca42
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Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

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