Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components

The past few decades have seen an increased emphasis on the involvement of the mitochondrial-associated membrane (MAM) in various neurodegenerative diseases, particularly in Parkinson’s disease (PD) and Alzheimer’s disease (AD). In PD, alterations in mitochondria, endoplasmic reticulum (ER), and MAM...

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Autores principales:	Tuladhar Sunanda, Bipul Ray, Arehally M. Mahalakshmi, Abid Bhat, Luay Rashan, Wiramon Rungratanawanich, Byoung-Joon Song, Musthafa Mohamed Essa, Meena Kishore Sakharkar, Saravana Babu Chidambaram
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ER stress mitochondrial dysfunction mitochondrial-associated membrane (MAM) ER–mitochondria crosstalk brain renin angiotensin system Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/025705b4c6124221ab15e4eb14084b15
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spelling	oai:doaj.org-article:025705b4c6124221ab15e4eb14084b152021-11-25T16:53:37ZMitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components10.3390/biom111116692218-273Xhttps://doaj.org/article/025705b4c6124221ab15e4eb14084b152021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1669https://doaj.org/toc/2218-273XThe past few decades have seen an increased emphasis on the involvement of the mitochondrial-associated membrane (MAM) in various neurodegenerative diseases, particularly in Parkinson’s disease (PD) and Alzheimer’s disease (AD). In PD, alterations in mitochondria, endoplasmic reticulum (ER), and MAM functions affect the secretion and metabolism of proteins, causing an imbalance in calcium homeostasis and oxidative stress. These changes lead to alterations in the translocation of the MAM components, such as IP3R, VDAC, and MFN1 and 2, and consequently disrupt calcium homeostasis and cause misfolded proteins with impaired autophagy, distorted mitochondrial dynamics, and cell death. Various reports indicate the detrimental involvement of the brain renin–angiotensin system (RAS) in oxidative stress, neuroinflammation, and apoptosis in various neurodegenerative diseases. In this review, we attempted to update the reports (using various search engines, such as PubMed, SCOPUS, Elsevier, and Springer Nature) demonstrating the pathogenic interactions between the various proteins present in mitochondria, ER, and MAM with respect to Parkinson’s disease. We also made an attempt to speculate the possible involvement of RAS and its components, i.e., AT1 and AT2 receptors, angiotensinogen, in this crosstalk and PD pathology. The review also collates and provides updated information on the role of MAM in calcium signaling, oxidative stress, neuroinflammation, and apoptosis in PD.Tuladhar SunandaBipul RayArehally M. MahalakshmiAbid BhatLuay RashanWiramon RungratanawanichByoung-Joon SongMusthafa Mohamed EssaMeena Kishore SakharkarSaravana Babu ChidambaramMDPI AGarticleER stressmitochondrial dysfunctionmitochondrial-associated membrane (MAM)ER–mitochondria crosstalkbrain renin angiotensin systemMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1669, p 1669 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ER stress mitochondrial dysfunction mitochondrial-associated membrane (MAM) ER–mitochondria crosstalk brain renin angiotensin system Microbiology QR1-502
spellingShingle	ER stress mitochondrial dysfunction mitochondrial-associated membrane (MAM) ER–mitochondria crosstalk brain renin angiotensin system Microbiology QR1-502 Tuladhar Sunanda Bipul Ray Arehally M. Mahalakshmi Abid Bhat Luay Rashan Wiramon Rungratanawanich Byoung-Joon Song Musthafa Mohamed Essa Meena Kishore Sakharkar Saravana Babu Chidambaram Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
description	The past few decades have seen an increased emphasis on the involvement of the mitochondrial-associated membrane (MAM) in various neurodegenerative diseases, particularly in Parkinson’s disease (PD) and Alzheimer’s disease (AD). In PD, alterations in mitochondria, endoplasmic reticulum (ER), and MAM functions affect the secretion and metabolism of proteins, causing an imbalance in calcium homeostasis and oxidative stress. These changes lead to alterations in the translocation of the MAM components, such as IP3R, VDAC, and MFN1 and 2, and consequently disrupt calcium homeostasis and cause misfolded proteins with impaired autophagy, distorted mitochondrial dynamics, and cell death. Various reports indicate the detrimental involvement of the brain renin–angiotensin system (RAS) in oxidative stress, neuroinflammation, and apoptosis in various neurodegenerative diseases. In this review, we attempted to update the reports (using various search engines, such as PubMed, SCOPUS, Elsevier, and Springer Nature) demonstrating the pathogenic interactions between the various proteins present in mitochondria, ER, and MAM with respect to Parkinson’s disease. We also made an attempt to speculate the possible involvement of RAS and its components, i.e., AT1 and AT2 receptors, angiotensinogen, in this crosstalk and PD pathology. The review also collates and provides updated information on the role of MAM in calcium signaling, oxidative stress, neuroinflammation, and apoptosis in PD.
format	article
author	Tuladhar Sunanda Bipul Ray Arehally M. Mahalakshmi Abid Bhat Luay Rashan Wiramon Rungratanawanich Byoung-Joon Song Musthafa Mohamed Essa Meena Kishore Sakharkar Saravana Babu Chidambaram
author_facet	Tuladhar Sunanda Bipul Ray Arehally M. Mahalakshmi Abid Bhat Luay Rashan Wiramon Rungratanawanich Byoung-Joon Song Musthafa Mohamed Essa Meena Kishore Sakharkar Saravana Babu Chidambaram
author_sort	Tuladhar Sunanda
title	Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
title_short	Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
title_full	Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
title_fullStr	Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
title_full_unstemmed	Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components
title_sort	mitochondria-endoplasmic reticulum crosstalk in parkinson’s disease: the role of brain renin angiotensin system components
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/025705b4c6124221ab15e4eb14084b15
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Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components

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